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Table 2 Amino acid changes during consecutive passages of rgY55sub (H9N2)

From: H9N2 influenza virus acquires intravenous pathogenicity on the introduction of a pair of di-basic amino acid residues at the cleavage site of the hemagglutinin and consecutive passages in chickens

Passage number

PB2

HA

NP

NA

M2

 

271a

29

234

357

391

54

195

51

P0

T

N

L

A

N

W

T

I

P1-P5

.b

.

Q

.

.

.

.

.

P6

.

H

Q

D

.

.

A

T

P7

.

H

Q

D

N/Dc

.

A

T

P8

T/A

H

Q

D

N/D

.

A

T

P9

T/A

H

Q

D

N/D

G

A

T

P10

A

H

Q

D

D

G

A

T

  1. a Methionine encoded by the AUG start codon is defined as position 1.
  2. b Periods indicate same amino acids as the parental virus.
  3. c Amino acid quasispecies are observed.
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Virology Journal

ISSN: 1743-422X