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Table 2 Results of the ROC analysis for three separate dilution steps and the combined data set

From: Highly sensitive detection of the group A Rotavirus using Apolipoprotein H-coated ELISA plates compared to quantitative real-time PCR

  AUC Cutpoint Sensitivity Specificity Correctly classified LR+ LR- theta0 d0 (range) IR upper limit (range) lower limit (range) VRP
Undiluted 0.9957 ≥ 0.42 95.24% 100.00% 96.88%   0.0476 0.931 0.360 (0.283, 0.653) 0.000 0.416 (0.19, 0.416) 0.424 (0.283, 0.489) 1.003
1:10 diluted 0.9667 ≥ 0.4551 90.00% 100.00% 93.75%   0.1 0.908 0.352 (3, 3) 0.000 0.328 (0.205, 0.328) 2.605 (3, 1.528) 1.764
1:100 diluted 0.9595 ≥ 0.21 89.47% 100.00% 93.75%   0.1053 0.909 0.174 (3, 1.642) 0.000 0.162 (0.067, 0.162) 3.000 (3, 0.383) 1.946
Overall 0.9708 ≥ 0.2122 95.00% 88.89% 92.71% 85.500 0.0562 0.917 0.264 (0.283, 0.416) 0.000 0.236 (0.09, 0.416) 0.571 (0.283, 1.017) 1.112
  1. A non-parametric analysis was performed;
  2. Abbreviations: Overall: all dilution steps were analysed together; AUC: area under the ROC-curve; LR+/LR-: Positive and negative likelihood ration; theta0/d0: co-ordinates at cut-off point of equivalence with specificity = sensitivity = theta0; IR: intermediate range, VRP: valid range proportion