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Figure 2 | Virology Journal

Figure 2

From: Sequence similarity between the erythrocyte binding domain of the Plasmodium vivax Duffy binding protein and the V3 loop of HIV-1 strain MN reveals a functional heparin binding motif involved in binding to the Duffy antigen receptor for chemokines

Figure 2

Polyanion inhibition of PvRII binding to DARC+ erythrocytes. Heparin, pentosan polysulfate, and the algal-derived sulfated polysaccharides Ca-spirulan, and Na-hornan (Na-HOR) have been shown to have potent inhibitory activity against HIV binding and infection. Chondroitin sulfate C does not and serves as a control. Inhibition of DARC+ erythrocytes binding to the DBP binding site was determined by comparing the number of COS-7 cells expressing pvRII with rosettes of polyanion-treated DARC+ human erythrocytes (per 20 fields at 200× magnification) with the number of rosettes of untreated erythrocytes.

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Virology Journal

ISSN: 1743-422X