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Table 1 Etiology of prion diseases

From: An overview of animal prion diseases

Animal prion diseases
Disease Host Etiology Year of Description
Scrapie Sheep, Goats Infection with Prions of unknown origin 1732
TME Mink Infection with Prions of either sheep or cattle origin 1947
CWD Cervids Infection with Prions of unknown origin 1967
BSE Cattle Infection with Prions of unknown origin 1986
EUE Nyala, Kudu Infection with Prions of BSE origin 1986
FSE Cats Infection with prions of BSE origin 1990
NHP Lemurs Infection with Prions of BSE origin 1996
Human prion diseases
Disease Host Etiology Year of Description
Kuru Human Ritualistic Cannibalism or "Transumption" 1900s
sCJD Human Spontaneous PrPC →PrPSc conversion or somatic mutation 1920
fCJD Human Mutations in PRNP 1924
GSS Human Mutations in PRNP 1936
iCJD Human Infection with Prions of human origin by cadaveric corneal grafts, hGH or dura mater 1974
FFI Human PRNP haplotype 178N-129M 1986
vCJD Human Infection with Prions of BSE origin 1996
sFI Human Spontaneous PrPC →PrPSc conversion or somatic mutation 1999
VPSPr Human Spontaneous PrPC →PrPSc conversion or somatic mutation 2008
  1. TME (transmissible mink encephalopathy), CWD (chronic wasting disease), BSE (bovine spongiform encephalopathy), EUE (exotic ungulate spongiform encephalopathy), FSE (feline spongiform encephalopathy), NHP (TSE in non-human primates), sCJD (sporadic Cruetzfeldt-Jacob disease), fCJD (familial CJD), GSS (Gerstmann-Sträussler-Scheinker syndrome), iCJD (iatrogenic CJD), FFI (fatal familial insomnia), vCJD (variant CJD), sFI (sporadic fatal insomnia), VPSPr (variably protease-sensitive prionopathy)