An overview of animal prion diseases

Table 1 Etiology of prion diseases

Animal prion diseases
Disease	Host	Etiology	Year of Description
Scrapie	Sheep, Goats	Infection with Prions of unknown origin	1732
TME	Mink	Infection with Prions of either sheep or cattle origin	1947
CWD	Cervids	Infection with Prions of unknown origin	1967
BSE	Cattle	Infection with Prions of unknown origin	1986
EUE	Nyala, Kudu	Infection with Prions of BSE origin	1986
FSE	Cats	Infection with prions of BSE origin	1990
NHP	Lemurs	Infection with Prions of BSE origin	1996
Human prion diseases
Disease	Host	Etiology	Year of Description
Kuru	Human	Ritualistic Cannibalism or "Transumption"	1900s
sCJD	Human	Spontaneous PrP^C →PrP^Sc conversion or somatic mutation	1920
fCJD	Human	Mutations in PRNP	1924
GSS	Human	Mutations in PRNP	1936
iCJD	Human	Infection with Prions of human origin by cadaveric corneal grafts, hGH or dura mater	1974
FFI	Human	PRNP haplotype 178N-129M	1986
vCJD	Human	Infection with Prions of BSE origin	1996
sFI	Human	Spontaneous PrP^C →PrP^Sc conversion or somatic mutation	1999
VPSPr	Human	Spontaneous PrP^C →PrP^Sc conversion or somatic mutation	2008

TME (transmissible mink encephalopathy), CWD (chronic wasting disease), BSE (bovine spongiform encephalopathy), EUE (exotic ungulate spongiform encephalopathy), FSE (feline spongiform encephalopathy), NHP (TSE in non-human primates), sCJD (sporadic Cruetzfeldt-Jacob disease), fCJD (familial CJD), GSS (Gerstmann-Sträussler-Scheinker syndrome), iCJD (iatrogenic CJD), FFI (fatal familial insomnia), vCJD (variant CJD), sFI (sporadic fatal insomnia), VPSPr (variably protease-sensitive prionopathy)

ISSN: 1743-422X