Figure 2
From: The matrix (M) protein of newcastle disease virus binds to human bax through its BH3 domain
A comparison between Bcl-2 homology domains of Bcl-2 family members and sequences from NDV strain AF2240 viral proteins. Only identical residues between AF2240 proteins and Bcl-2 family members are highlighted. A. BH1 domain-like regions. Note that five out of nine residues of AF2240-F and Mcl-1 in this region are identical. Most conserved residues asparagine, glycine and valine are highlighted in green. B. BH2 domain-like regions. A few conserved amino acid residues observed. C. BH3 domain-like regions. Most conserved amino acid residues leucine, glycine and aspartic acid are highlighted in green. D. BH4 domain-like regions. Only AF2240-F shows four identical residues to a small segment of the BH4 domains. E. A comparison of BH3 domain-like regions between individual proteins of NDV strain AF2240 virus. Note that this domain is present in four different proteins. Conserved amino acid residues leucine, glycine and aspartic acid are present in three out of the four viral proteins (highlighted in green). AF2240-F and AF2240-HN share many similar residues but the conserved glycine residue is missing in AF2240-HN.