Table 4 Nucleotide changes leading to amino acid substitutions in F, L, M2-1 and M2-2 proteins exclusively in primary clinical HRSVA strains as compared to reference strains

F

CTC/CTT → TTT

L-15-F

RSV-1, RSV-2,RSV-7 to RSV-10

L

GAC → AAC/TAC

D-148-N/Y

RSV-1, RSV-2, RSV-4 to

GTC/GAC → GGC

V/D-174-G

RSV-10, RSV-14

RSV-1 to RSV-9, RSV-14

M2-1

ATA → CTA

I-87-L

RSV-12 to RSV-14

AAA → AGT

N-117-S

RSV-8, RSV-10, RSV-11

M2-2*

ATG → ACG

M-1-T

RSV-1, RSV-2, RSV-5, RSV-8 to RSV-14

ACT → AAT

T-18-N

RSV-1, RSV-2, RSV-5, RSV-7 to RSV-14

AGA → AAT/AGT

R-25-N/S

RSV-1, RSV-2, RSV-5, RSV-8 to RSV-14

TTC → ATC

F-39-I

RSV-12 to RSV-14

CCA → CAA

P-44-Q

RSV-1, RSV-2, RSV-4, RSV-5, RSV-8 to RSV-14

ATG → ATA/ACG

M-48-I/T

RSV-1, RSV-2, RSV-5, RSV-7 to RSV-14

CCA → CAG

P-51-Q

RSV-12 to RSV-14

ACA → CCA

T-54-P

RSV-1, RSV-2, RSV-4 to RSV-14

ACA → GCA

T-68-A

RSV-1 to RSV-14

ATT → ACT

I-69-T

RSV-3 to RSV-10, RSV-14

ATT → ACT

I-79-T

RSV-1 to RSV-6, RSV-8, RSV-9, RSV-12 to RSV-14

GAG → GAT

E-80-D

RSV-1 to RSV-14