Whole genome characterization of non-tissue culture adapted HRSV strains in severely infected children

Table 2 Amino acid variability (%) identified in individual proteins of HRSVA: Comparison between hospitalized strains

Strain	HRSVA Proteins (% Amino acid variability)
	NS1	NS2	N	P	M	SH	G	F	L	M2-1	M2-2
RSV-1¹
RSV-2	0.7	2.4	0.25	0	0	0	5.4	1.21	0.27	0.25	0
RSV-3	0	0	0.25	0.4	0	0	5.4	1.74	1.06	0.33	0.88
RSV-4	0	0	0.5	0	0	0	2.34	1.91	1.01	0.33	0.44
RSV-5	0	0	0	0.4	0	0	3.3	1.91	0.18	0.25	0
RSV-6	0	0	0	0	0	0	2.7	1.91	0.69	0.33	0.55
RSV-7	0	0	0.5	0	0	0	2.7	1.74	0.2	0.33	0.44
RSV-8	0	0	0	0	0	0	2.01	1.39	0.46	0.25	0
RSV-9	0	0	0	0	0	0	2.34	1.21	0.54	0.38	0
RSV-10	0	0	0.25	0.4	0	0	2.01	1.56	1.08	0.38	0.33
RSV-11	0.7	2.4	0.5	0	0	0	6.4	2.09	1.15	0.38	0.44
RSV-12	0	0	0.5	0.4	0	0	5.4	1.91	1.38	0.55	0.55
RSV-13	0	0	0.5	0.4	0	0	6.4	2.61	1.47	0.60	0.55
RSV-14	0	0	0.5	0	0	0	5.7	2.61	0.55	0.55	0.44

HRSVA2 (lab adapted strain) is passaged several times in cell culture, thus may have numerous culture mediated mutations. Therefore, RSV-1, a strain obtained from a hospitalized RSVA patient is used as a reference strain for comparative analysis of the proteins of RSVA strains from clinical source.

ISSN: 1743-422X