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Figure 12 | Virology Journal

Figure 12

From: Mechanism of HCV's resistance to IFN-α in cell culture involves expression of functional IFN-α receptor 1

Figure 12

Schematic diagram summarizing the amino acid deletion of extracellular domain of IFNAR1 protein found in the IFN-α resistant Huh-7 cells. Left panel: Four extracellular domains of IFNAR1 in the sensitive cell line with no deletion. Middle panel: 58 amino acid deletions in the SD1 domain in the R-15 and R-24 series clones. Right panel: 50 amino acid deletions in the SD-4 domain of the R-17 series clones. The three series of cell lines demonstrate different variants of IFNAR1 and how the signaling is blocked due to the deletion of extracellular domains of IFNAR1.

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Virology Journal

ISSN: 1743-422X