Human cell types important for Hepatitis C Virus replication in vivo and in vitro. Old assertions and current evidence

Revie, Dennis; Salahuddin, Syed Zaki

doi:10.1186/1743-422X-8-346

Virology Journal

Table 7 Quasispecies analyses of HCV in various tissues in chronic HCV-infected individuals

From: Human cell types important for Hepatitis C Virus replication in vivo and in vitro. Old assertions and current evidence

Patients, special groups	Cell types investigated	Regions studied	Methods	References
a. Liver, PBMC, other
End-stage liver disease	L, S, PBMC, PLN	HVR1	Seq	[41]
LT	L, S, PBMC, PLN	HVR1	HMA, Seq	[101]
LT	L, S, PBMC, PLN	HVR1	Seq	[66]
IFN α-treated and SVR occult	L, S, PBMC	5'UTR	Seq	[61]
IFN α-treated and SVR occult	L, S, PBMC, PLN	HVR1	Seq	[100]
Chronic	L, P, PBMC	HVR1	Seq	[60]
Chronic	L, S, PBMC	HVR1	Clonal frequency analysis, Seq	[212]
Chronic	L, S, PBMC	HVR1	Seq	[196]
Chronic	L, S, P, PBMC, monocytic DC	5'UTR, HVR1	Seq	[78]
Chronic	L, P, PBMC	5'UTR	INNO-LiPA	[62]
b. Liver, other
Cadavers	L, S, CNS, lymph	5'UTR, HVR1	Seq	[79]
Co-infected	L, P, CNS	5'UTR, E1	Seq	[80]
Chronic	L, S	5'UTR, E2-NS2	Seq	[86]
Chronic	L, S	E2-NS2	Seq	[87]
Chronic	L, S	E2-NS2	Seq	[88]
Chronic	L, P, CNS	5'UTR, E1	Seq	[81]
Chronic	L, S	5'UTR	SSCP, Seq	[89]
Chronic	L, PBMC, monocytic DC	5'UTR	Seq	[77]
c. PBMC, other extrahepatic
Co-infected	P, PBMC, CSF	5'UTR	Seq, INNO-LiPA	[75]
Co-infected	S, PBMC, M, B, CD4+ T, CD8+ T	5'UTR	SSCP, Seq	[70]
Co-infected	S, PBMC	HVR1	Seq	[105]
Co-infected women	P, PBMC, Genital-cervicovaginal lavage fluid (CVL)	5'UTR	SSCP, Seq	[90]
LT	S, PBMC	5'UTR	SSCP, Seq	[98]
LT	P, PBMC	HVR1	Seq	[99]
LT	S, PBMC	5'UTR	SSCP, Seq	[213]
LT	S, PBMC	NS5B	Seq	[66]
MC	P, PBMC, cryoprecipitate	5'UTR, HVR1	Seq	[65]
Chronic	P, PBMC	5'UTR, NS5B	Seq	[214]
Chronic	P, PBMC	5'UTR, HVR1	Seq	[69]
Chronic	P, PBMC	5'UTR, NS5B	SSCP, Seq, INNO-LiPA	[63]
Chronic	S, PBMC, CSF	5'UTR	SSCP, Seq	[82]
Chronic	P, PBMC	5'UTR	SSCP, Seq	[67]
Chronic	S, PBMC	HVR1,2+	Seq	[64]
d. Other extrahepatic
Cadavers	S, CNS (brain autopsies)	5'UTR	SSCP, Seq	[84]
Co-infected	S, CSF	5'UTR, HVR1	SSCP	[83]
Co-infected women	P, Genital-cervical cytobrush	5'UTR, HVR1	Seq	[91]
Co-infected men	P, Semen	HVR1	Seq	[92]
LT	S, Brain	5'UTR	SSCP, Seq	[85]
Oral lichen planus, oral cancer	Oral lichen planus, oral cancer	5'UTR, HVR1	Seq	[74]
Chronic	S, peripheral blood DC	HVR1	Seq	[72]
Chronic	P, BMC	5'UTR	SSCP, Seq, INNO-LiPA	[76]
Chronic	P, B, M, T	HVR1	Seq	[71]
Chronic	P, peripheral blood DC	HVR1	Seq	[73]
Chronic	P, M, B, CD4+ T, CD8+ T	5'UTR	Seq	[58]

Key: L = Liver; S = Serum; P = Plasma; B = B cells; T = T cells; M = Monocytes/Macrophages; DC = Dendritic cells; CSF = cerebral spinal fluid;
PLN = perihepatic lymph nodes; LT = Liver transplant; MC = mixed cryoglubulinemia; SSCP = single-strand conformational polymorphism; HMA = heteroduplex mobility;

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ISSN: 1743-422X

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