Human cell types important for Hepatitis C Virus replication in vivo and in vitro. Old assertions and current evidence

Table 1 HCV negative strand RNA detection by regular RT-PCR in chronic HCV-infected individuals

Patients, Special groups	Results for negative strand by PCR	Ratio of +/- strands	References
HCC	5/5 L, 0/5 S	1 to 100 L	[26]
Hemophilia	14/27 P, 20/27 PBMC		[148]
Hemophilia	14/19 S, 14/14 PBMC		[149]
HIV-HCV co-infected	4/6 PBMC, 0/6 P	8-50 PBMC	[150]
IFN α-treated	3/11 P untreated; 1/11 treated PBMC		[151]
IFN α-treated	10/10 untreated; 7/9 nonresponders, 2/6 responders PBMC		[152]
Mixed cryoglobulinemia	4/6 PBMC, 5/7 BM		[153]
NHL	6/8 B		[154]
Normal livers	4/4 L, 4/4 PBMC		[155]
Oral lichen planus, oral cancer	3/19 Oral lichen planus; 5/7 Oral cancer		[74]
Chronic	0/5 S, 1/5 PBMC		[156]
Chronic	7/13 PBMC untreated, 5/8 PBMC treated		[157]
Chronic	15/15 L, 0/13 P, 2/3 PBMC, 5/9 BM		[158]
Chronic	0/3 S, 3/3 PBML		[159]
Chronic	L, PBML, B positive (no numbers); Not T, NK		[160]
Chronic	8/9 L, 5/9 S	10-1000 L; 1-10 S	[25]
Chronic	0/19 PBMC, M, T, NK; 3/19 B, 3/19 DC		[73]
Chronic	1/1 L, 10/11 S		[161]
Chronic	28/51 B, 0/14 T, 1/24 M, 19/47 PML		[162]
Chronic	3/5 S, 5/5 PBMC, 3/3 B, 3/3 T, 2/3 M		[163]

Key: L = Liver; S = Serum; P = Plasma; B = B cells; T = T cells; M = Monocytes/Macrophages; BM = Bone marrow cells; DC = Dendritic cells; PBML = Peripheral blood mononuclear lymphocytes; PMNG = Polymorphonuclear granulocytes; PML = Polymorphonuclear leukocytes;

ISSN: 1743-422X