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Figure 1 | Virology Journal

Figure 1

From: Characterization of a branched lipopeptide candidate vaccine against influenza A/Puerto Rico 8/34 which is recognized by human B and T-cell immune responses

Figure 1

Sixteen synthetic peptides consisting of a T-helper epitope (SFERFEIFPKE) linked to an immunodominant B-cell epitope (WLTEKEGSYP) based on the hemagglutinin of influenza virus A/Puerto Rico/8/34 were synthesized. Peptide 122 was a simple, unmodified T-B diepitope construct. Peptides 123-128 are multiple antigen peptides (MAPs, as depicted schematically in Figure 2), where „ÄČK designates a lysine branching point; peptides 124, 128 and 131 are lipidated with palmitic acid, as indicated by CH 3 (CH 2 ) 14 COOH; peptides 132-138 are mutated versions of the original A/Puerto Rico/8/34 T-helper and B-cell epitopes, with each mutation shown in bold type (as summarized in Figure 1).

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