Skip to main content
Figure 6 | Virology Journal

Figure 6

From: Immunogenicity in mice and rhesus monkeys vaccinated with recombinant vaccinia virus expressing bivalent E7E6 fusion proteins from human papillomavirus types 16 and 18

Figure 6

Specific T cell responses were tested directly ex vivo in IFN-γ Elispot assays with PBMCs in rhesus monkeys. The rhesus monkeys (n = 3 per group) were immunised intradermally in the left leg twice with PBS (numbers 1, 2 and 3), rVVJ1175 (numbers 4, 5 and 6) or rVVJ16/18E7E6 (numbers 7, 8 and 9). The monkeys were primed with 1 × 107 pfu recombinant vaccinia virus at day 0 and boosted with 5 × 107 pfu recombinant vaccinia virus at day 11. PBMCs from all three groups of vaccinated monkeys were analysed for HPV-specific cellular immunity against medium (without peptides) and peptide pools E7 or E6 of HPV type 16 and 18 by IFN-γ Elispot assays at days -2 and 53.

Back to article page

Virology Journal

ISSN: 1743-422X