Genetic drift evolution under vaccination pressure among H5N1 Egyptian isolates

Table 3 Amino acid sites associated with virulence to mammals in Egyptian avian and human isolates

H5 Numbering			Egyptian Isolates
	Residue	Human n = 94	Isolates in the current study				Sequences of Egyptian avian isolates in the GenBank					Reference
			F7	F8	F9	F10	2006	2007	2008	2009	2010
							n = 37	n = 78	n = 82	n = 74	n = 44
86	V^v/A, I, P, S, T	A⁹⁰/S²/T²	2A	A	A	A	A	A⁷⁷/V¹	A⁷⁹/S²/V¹	A⁶⁹/V⁵	A⁴²/S¹/T¹	[32]
124	S^v/N, D	D⁸⁸/N⁶	D	D	D	D	D ³⁶/N ¹	D⁶³/N¹⁴/H¹	D⁶⁷/N¹⁵	D⁷²/N²	D⁴²/N²	[32]
138	L^v, N^v/Q, H, I	Q	Q	Q	Q	Q	Y	Y⁷²/H⁶	Q⁸⁰/H¹/K¹	Q⁷²/H²	Q⁴²/H¹/K¹	[32]
156	T^v/S^v/A	A⁹³/T¹	A	A	A	T	A	A⁷⁷/V¹	A⁶⁶/T¹⁶	A⁵¹/T²³	A²⁷/T¹⁷	[32–34]
212	E^v/R^v/K	K⁹³/Q¹	K	K	K	K	K	K	K⁸¹/T¹	K⁷⁰/R⁴	K	[32]
263	T^v/A	T	T	T	T	T	T	T	T⁸¹/A¹	T	T	[32]

Numerical superscripts denote the number of isolates that possess the specified amino acid residue.
V superscript denotes a residue that has been found to be associated with an increase in the virulence of H5N1 to mammals.

ISSN: 1743-422X