Table 2 Comparative representation of the distribution of haemagglutinin epitopes that showed variation among avian and human H5N1 Egyptian isolates

110

115

117

119

121

122

124

126

127

129

130

136

152

F7

H

Q

I

K

S

W

D

E

A

Δ

G

P

K

F8

H

Q

I

K

S

W

D

E

A

Δ

G

P

K

F9

H

Q

I

K

S

W

D

E

A

S

G

P

K

F10

R

Q

I

K

S

W

D

E

A

L

G

P

K

2006

H

Q

I

K

S

W

D³⁶/N¹

E

A

S

G

P

K

2007

H⁷¹/R⁷

Q⁷⁷/K¹

I⁷⁶/F²

K⁷²/N⁶

S⁷⁷/C¹

W

D⁶³/N¹⁴/H¹

E

A⁷⁵/T³

S⁶⁶/L⁶/Δ⁶

G

P

K

2008

H³²/R⁵⁰

Q⁸¹/H¹

I⁷⁵/F⁷

K⁸⁰/R²

S⁸⁰/P¹/Y¹

W

D⁶⁷/N¹⁵

E

A

S⁶⁶/L¹⁶

G⁸¹/R¹

P⁷⁷/Q³/S²

K

2009

H⁵⁰/R²⁴

Q⁶⁹/K⁵

I⁶⁷/F⁴/T³

R⁷³/S¹

S⁷³/Y¹

W

D⁷²/N²

E

A

Δ³⁶/L²²/S¹⁶

G

P⁷²/Q²

K⁷⁰/E⁴

2010

H²⁷/R¹⁷

Q³⁴/K¹⁰

I⁴³/T¹

K

S

W⁴³/C¹

D⁴²/N²

E⁴³/G¹

A

Δ²⁶/L¹⁸

G

P

K³⁹/E⁴/G¹

Human

H⁹³/R¹

Q

I

K

S

W

D⁸⁸/N⁶

E⁹³/G¹

A⁹³/T¹

Δ⁵⁰/L¹/S⁴³

G

P

K⁹²/Q²

Strain

139

140

141

144

147

174

178

181

30

257

263

278

F7

G

R

S

F

V

V

I

P

Q

V

T

C

F8

G

R

S

F

V

V

I

P

Q

V

T

C

F9

G

R

S

F

V

V

I

P

Q

V

T

C

F10

G

G

P

Y

V

V

I

P

Q

V

T

C

2006

G

G

S³⁵/A²

F

V

V

I

P

Q

V

T

C

2007

G

R⁵⁹/K⁸/G⁷ I³/S¹

S⁶⁴/P¹⁴

F⁷¹/Y⁷

V⁷⁶/M²

V⁷⁷/I¹

I

P

Q

V

T

C

2008

G

G⁴⁷/R³⁴/E¹

P⁴⁹/S³⁰/T²/L¹

F³²/Y⁵⁰

V⁸⁰/M²

V⁸⁰/I²

I⁸¹/V¹

P⁸¹/T¹

Q⁸⁰/K²

V

T⁸¹/A¹

C

2009

G

R⁵¹/G²⁰/E¹ I¹/S¹

S⁴⁶/P²³/T²/L³

F⁵¹/Y²³

V

V⁶⁹/I⁵

I

P⁷³/S¹

Q

V⁷³/I¹

T

C⁷³/F¹

2010

G⁴³/R¹

S²⁸/P¹⁰/L⁵/T¹

S²⁸/P¹⁰/L⁵/T¹

F²⁸/Y¹⁶

V

V⁴²/I²

I

P

Q

V

T

C

Human

G

R⁹¹/G²/K¹

S⁹¹/P³

F⁹³/Y¹

V

V⁹²/I²

I

P

Q

V

T

C

86

101

105

151

154

155

156

158

159

161

163

185

192

F7

A

L

L

T

D

N

A

P

T

K

S

T

Q

F8

A

L

L

T

D

N

A

P

T

K

S

T

Q

F9

A

L

L

I

N

N

A

P

T

K

S

A

H

F10

A

L

L

I

N

N

T

P

T

K

S

E

K

2006

A

L

L

I

D³⁴/N³

N

A

P

T

K

S

A

Q

2007

A⁷⁷/V¹

L⁷⁷/M¹

L⁷⁷/F¹

T⁶/I⁷²

D⁶⁵/N¹⁰/G²/B¹

N

A⁷⁷/V¹

P

T

K

S

A

Q

2008

A⁷⁹/S²/V¹

L

L⁸¹/S¹

T⁴/I⁷⁷/V¹

D⁶²/N¹⁶/G³/E¹

N⁸¹/T¹

A⁶⁶/T¹⁶

P

T

K⁷⁶/E⁵/T¹

S⁷⁷/N²/T²/R¹

A⁷²/E⁷/T³

Q⁶⁸/K¹⁴

2009

L⁶⁹/V⁵

L

L

T³⁶/I³⁰/L⁴/V⁴

D⁴³/N³⁰/G¹

N⁷¹/S²/D¹

A⁵¹/T²³

P

T⁶⁹/L³/I²

K⁷³/R¹

S⁷³/N¹

A⁵²/E²⁰/T²

Q⁴⁷/K²¹/H⁶

2010

L⁴²/S¹/T¹

L⁴³/M¹

L

T²⁸/I¹⁶

N³²/D¹²

N⁴³/D¹

A²⁷/T¹⁷

P⁴³/L¹

T³⁹/L⁵

K

S³⁹/N⁵

A²⁸/E¹²/T³/V¹

Q²⁷/K¹⁷

Human

A⁹⁰/S²/T²

L

L

T⁵⁰/I⁴⁴

D⁶¹/N²⁹/G³/E¹

N⁹³/S¹

A⁹³/T¹

P

T

K

S

A⁸⁸/E³/T³

Q⁸⁹/H⁴/K¹

Strain

197

198

199

210

212

226

43

47

66

71

72

75

83

244

249

F7

Y

I

S

V

K

M

N

V

M

L

N

E

I

N

A

F8

Y

I

S

V

K

M

N

V

M

L

N

E

I

N

A

F9

Y

I

S

V

K

M

D

V

M

L

N

E

I

N

A

F10

Y

I

S

V

K

V

D

V

M

P

N

E

I

N

A

2006

Y

I

S

V

K

M³⁵/I²

D

V

M

L

N

E

I

N

A

2007

Y⁷⁷/Q¹

I

S

V

K

M⁴⁶/V⁷/I²⁵

D⁷²/N⁶

V⁷⁷/M¹

M⁷⁷/L¹

L⁷⁷/H¹

N⁷²/D⁶

E

I⁷⁷/V¹

N

A

2008

Y

I

S⁸⁰/P¹

V⁷⁶/I⁶

K⁸⁰/T¹

M²³/V⁴⁹/I¹⁰

D⁷⁸/N⁴

V

M

L⁷³/P⁵/F⁴

N

E⁸¹/K¹

I

N

A

2009

Y

I

S

V

K⁷⁰/R⁴

M⁴³/V²³/I⁸

D³⁸/N³⁶

V

M

L⁵⁵/P¹⁹

N

E

I⁶⁸/T⁴/S²

N⁷³/D¹

A

2010

Y

I⁴³/V¹

S

V⁴³/A¹

K

M²⁷/V¹⁷

D¹⁷/N²⁶/S¹

V

M

L³²/P¹²

N

E

I³⁹/T⁵

N

A⁴³/V¹

Human

Y

I

S

V⁹³/I¹

K⁹³/Q¹

M⁹⁰/V¹/I³

D⁴⁴/N⁵⁰

V⁹³/M¹

M

L

N

E

I

N

A