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Table 2 Frequencies of IL-10 Promoter Alleles and Genotype/Haplotypes in Patients With HBV and healthy Control Population

From: Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis B to interferon alfa

  patients (%) control (%) OR P
Allele n = 52 × 2 n = 48 × 2   
   - 1082G 4(3.9) 3(3.1) 1.24 0.99
   - 1082A 100(98) 93(96.8) 0.81 0.99
   - 819C 18(17.3) 18(18.7) 0.91 0.85
   - 819T 86(92.7) 78(81.3) 1.97 0.85
  38(36.5) 22(22.9) 1.88 0.05
   - 592A 66(63.4) 74(77.1) 0.52 0.05
Genotype n = 52 n = 48   
   - 592 A/A 23 (44.2) 30 (62.5) 0.48 0.08
A/C 20(38.4) 14(29.2) 1.52 0.40
C/C 9(17.3) 4(8.3) 2.3 0.24
   - 819T/T 36(69.2) 33(68.8) 1.02 0.99
T/C 12(23.1) 12(23.1) 0.9 0.99
C/C 4(7.7) 4(7.7) 1.25 0.99
   - 1082 A/A 48(92.3) 45(93.8) 0.8 0.99
A/G 4(7.7) 3(6.3) 1.25 0.99
G/G 0(0) 0(0)   
   Heplotype(-1082/-819/-592)    
  n = 52 n = 48   
GCC 4 (7.6) 3(6.2) 1.25 0.99
ACC 13 (25) 14(29.1) 0.81 0.66
ATA 41 (78.8) 43(89.5) 0.43 0.18
GTA 2 (3.8) 2(4.1) 0.92 0.99
  1. NOTE: n is the number of patients or controllers. P values were caculated by Fisher Probability. P values less than 0.05 were considered statistically significant. SR: sustained response; NR: non-responders.