Figure 4

The dominant proportion of the central memory phenotype was found in CD127^loCD25^hiFoxP3⁺ Tregs in CHC patients. (A) Representative dot plot analysis showing the phenotypic distribution of CD127^loCD25^hiFoxP3⁺ Tregs depending on expression of CD27 and CD45RA. (B) Frequency of Naïve -Tregs (□) was dramatically reduced in CHC patients compared with HCs while TEM (▥)/Effector (▦) -Tregs showed a higher levels in CHC compared with in HCs. (C) The percentage of naïve and effector subset decreased while the percentage of TCM subset increased in Tregs compared with in their total CD4⁺ T cell counterparts. *P < 0.05; **P < 0.01; ***P < 0.001.