The severity of VMC were evaluated by histopathological examination. A. Representative of myocardial histopathologic images in VMC group(H&E, original magnification × 400). Myocardial was normal on Day 0. A few scattered small foci of myocyte necrosis were observed on Day 7. The severity of myocardial necrosis and interstitial inflammatory cell infiltration were markedly increased on Day 14. Then the degree of inflammation gradually decreased. Fibrous hyperplasia was found from Day 28 on. B. The results of statistical analysis for pathological scores in different groups. n = 5 mice for per control subgroup, n = 6-10 for per VMC subgroup. Values are expressed as mean ± SD. *, p < 0.01 vs. control subgroups sacrificed on the same time point; #, p < 0.05 vs. other VMC subgroups. VMC, Viral myocarditis.