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Table 1 Human genes induced by HSV infection of NHEK cells at 9h after infection

From: Herpes simplex virus induces the marked up-regulation of the zinc finger transcriptional factor INSM1, which modulates the expression and localization of the immediate early protein ICP0

Representative Public ID a Gene Symbol Gene Title Fold change b Gene Ontology Biological Process
    HSV-1 HSV-2  
    WT ΔUS3 WT ΔUS3  
NM_005083 U2AF1L1 U2 small nuclear RNA auxillary factor 1-like 1 4.0 13.0 5.3 7.5 ---
AV712346 REEP5 Receptor accessory protein 5 9.8 11.3 11.3 9.8 ---
AK091308 NARG1 NMDA receptor regulated 1 26.0 59.7 36.8 19.7 ---
AW613101 KCNQ1OT1 KCNQ1 overlapping transcript 1 32.0 45.3 42.2 78.8 ---
AW014728 FLJ39575 hypothetical protein FLJ39575 90.5 111.4 78.8 207.9 ---
AL359567 IGSF4 Immunoglobulin superfamily, member 4 8.0 17.1 10.6 7.5 immune response
NM_000594 TNF tumor necrosis factor (TNF superfamily, member 2) 21.1 34.3 8.6 11.3 immune response
AW135003 API5 Apoptosis inhibitor 5 4.3 6.1 4.6 5.7 apoptosis
AW511239 RHOT1 Ras homolog gene family, member T1 4.9 6.1 6.5 8.6 apoptosis
AA005430 CROP Cisplatin resistance-associated overexpressed protein 7.0 13.0 13.0 9.8 apoptosis
NM_006538 BCL2L11 BCL2-like 11 (apoptosis facilitator) 39.4 29.9 19.7 39.4 apoptosis
NM_006910 RBBP6 retinoblastoma binding protein 6 4.0 6.5 6.1 6.1 cell cycle
NM_000076 CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 4.9 5.7 8.0 7.0 cell cycle
X07868 IGF2 insulin-like growth factor 2 (somatomedin A) 6.1 7.0 5.7 7.5 cell cycle
NM_015675 GADD45B growth arrest and DNA-damage-inducible, beta 12.1 14.9 14.9 34.3 cell cycle
NM_003914 CCNA1 cyclin A1 13.0 21.1 13.0 14.9 cell cycle
BE348555 PDZK1 PDZ domain containing 1 4.0 9.2 4.6 6.5 signal transduction
NM_005204 MAP3K8 mitogen-activated protein kinase kinase kinase 8 4.0 12.1 4.6 6.5 signal transduction
NM_003328 TXK TXK tyrosine kinase 5.7 5.3 9.8 10.6 signal transduction
NM_014823 WNK1 WNK lysine deficient protein kinase 1 6.1 5.3 9.8 7.0 signal transduction
AI684439 GRAP GRB2-related adaptor protein 13.9 8.6 6.1 16.0 signal transduction
NM_018390 PLCXD1 phosphatidylinositol-specific phospholipase C, X domain containing 1 11.3 34.3 17.1 19.7 signal transduction
AF069506 RASD1 RAS, dexamethasone-induced 1 111.4 104.0 111.4 207.9 signal transduction
NM_004692 INA internexin neuronal intermediate filament protein, alpha 6.5 9.8 4.6 4.6 cell adhesion and cytoskeleton
AI668588 SPTAN1 Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin) 16.0 27.9 26.0 26.0 cell adhesion and cyctoskeleton
NM_005382 NEFM neurofilament, medium polypeptide 150kDa 29.9 36.8 26.0 55.7 cell adhesion and cytoskeleton
U26662 NPTX2 neuronal pentraxin II 45.3 52.0 32.0 34.3 cell communication
NM_002105 H2AFX H2A histone family, member X 10.6 13.9 7.5 13.0 DNA / chromosome
NM_003655 CBX4 chromobox homolog 4 (Pc class homolog, Drosophila) 24.3 29.9 14.9 36.8 DNA/chromosome
AL832081 ZNF131 Zinc finger protein 131 4.3 7.0 6.1 9.8 transcription
T79183 JAZF1 JAZF zinc finger 1 5.7 4.9 7.5 8.6 transcription
D42040 BRD2 bromodomain containing 2 6.1 9.2 6.1 8.6 transcription
NM_001452 FOXF2 forkhead box F2 6.5 14.9 11.3 16.0 transcription
NM_005904 SMAD7 SMAD family member 7 7.0 9.8 7.0 12.1 transcription
AF193855 ZIC2 Zic family member 2 (odd-paired homolog, Drosophila) 13.0 55.7 34.3 68.6 transcription
NM_001674 ATF3 activating transcription factor 3 13.9 16.0 36.8 26.0 transcription
AI459175 KLF3 Kruppel-like factor 3 (basic) 14.9 18.4 16.0 14.9 transcription
NM_004405 DLX2 distal-less homeobox 2 17.1 24.3 13.9 42.2 transcription
AW274658 ING1 Inhibitor of growth family, member 1 19.7 12.1 10.6 24.3 transcription
NM_002166 ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 24.3 22.6 19.7 42.2 transcription
NM_002448 MSX1 msh homeobox 1 59.7 84.4 48.5 128.0 transcription
NM_152677 ZSCAN4 zinc finger and SCAN domain containing 4 97.0 362.0 55.7 147.0 transcription
AA761573 ZNF342 zinc finger protein 342 128.0 256.0 111.4 294.1 transcription
NM_002196 INSM1 insulinoma-associated 1 445.7 776.0 955.4 1782.9 transcription
AI906424 HNRPM Heterogeneous nuclear ribonucleoprotein M 4.3 5.7 6.5 11.3 RNA / translation
AI445255 SFRS3 Splicing factor, arginine/serine-rich 3 13.0 14.9 14.9 21.1 RNA / translation
R17062 PABPC1 Poly(A) binding protein, cytoplasmic 1 32.0 39.4 48.5 90.5 RNA / translation
BF195994 PIAS2 Protein inhibitor of activated STAT, 2 4.3 5.7 4.6 9.2 protein folding and modification
U56725 HSPA2 heat shock 70kDa protein 2 5.7 8.6 4.0 5.7 protein folding and modification
AU158573 ABHD5 Abhydrolase domain containing 5 13.0 18.4 11.3 19.7 protein folding and modification
NM_000104 CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 6.1 6.5 13.0 18.4 development
NM_001529 HHEX homeobox, hematopoietically expressed 17.1 48.5 97.0 68.6 development
NM_002405 MFNG MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase 4.0 8.0 4.6 8.6 developmental process
NM_000361 THBD thrombomodulin 9.8 11.3 5.7 8.6 biological regulation
NM_000499 CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 4.3 4.9 5.3 7.5 cellular metabolism
AI625747 ADRB1 adrenergic, beta-1-, receptor 6.1 18.4 7.5 10.6 cellular metabolism
NM_003895 SYNJ1 synaptojanin 1 6.5 13.0 7.5 11.3 cellular metabolism
NM_000558 HBA1 hemoglobin, alpha 1 55.7 84.4 34.3 137.2 transport
  1. a GeneBank accession No. corresponds to sequence to which the Affymetrix U133 plus 2 probe set was designed.
  2. b Fold change was calculated by comparison to values obtained from the mock-infected cells.