Table 1 Human genes induced by HSV infection of NHEK cells at 9h after infection

NM_005083

U2AF1L1

U2 small nuclear RNA auxillary factor 1-like 1

4.0

13.0

5.3

7.5

---

AV712346

REEP5

Receptor accessory protein 5

9.8

11.3

11.3

9.8

---

AK091308

NARG1

NMDA receptor regulated 1

26.0

59.7

36.8

19.7

---

AW613101

KCNQ1OT1

KCNQ1 overlapping transcript 1

32.0

45.3

42.2

78.8

---

AW014728

FLJ39575

hypothetical protein FLJ39575

90.5

111.4

78.8

207.9

---

AL359567

IGSF4

Immunoglobulin superfamily, member 4

8.0

17.1

10.6

7.5

immune response

NM_000594

TNF

tumor necrosis factor (TNF superfamily, member 2)

21.1

34.3

8.6

11.3

immune response

AW135003

API5

Apoptosis inhibitor 5

4.3

6.1

4.6

5.7

apoptosis

AW511239

RHOT1

Ras homolog gene family, member T1

4.9

6.1

6.5

8.6

apoptosis

AA005430

CROP

Cisplatin resistance-associated overexpressed protein

7.0

13.0

13.0

9.8

apoptosis

NM_006538

BCL2L11

BCL2-like 11 (apoptosis facilitator)

39.4

29.9

19.7

39.4

apoptosis

NM_006910

RBBP6

retinoblastoma binding protein 6

4.0

6.5

6.1

6.1

cell cycle

NM_000076

CDKN1C

cyclin-dependent kinase inhibitor 1C (p57, Kip2)

4.9

5.7

8.0

7.0

cell cycle

X07868

IGF2

insulin-like growth factor 2 (somatomedin A)

6.1

7.0

5.7

7.5

cell cycle

NM_015675

GADD45B

growth arrest and DNA-damage-inducible, beta

12.1

14.9

14.9

34.3

cell cycle

NM_003914

CCNA1

cyclin A1

13.0

21.1

13.0

14.9

cell cycle

BE348555

PDZK1

PDZ domain containing 1

4.0

9.2

4.6

6.5

signal transduction

NM_005204

MAP3K8

mitogen-activated protein kinase kinase kinase 8

4.0

12.1

4.6

6.5

signal transduction

NM_003328

TXK

TXK tyrosine kinase

5.7

5.3

9.8

10.6

signal transduction

NM_014823

WNK1

WNK lysine deficient protein kinase 1

6.1

5.3

9.8

7.0

signal transduction

AI684439

GRAP

GRB2-related adaptor protein

13.9

8.6

6.1

16.0

signal transduction

NM_018390

PLCXD1

phosphatidylinositol-specific phospholipase C, X domain containing 1

11.3

34.3

17.1

19.7

signal transduction

AF069506

RASD1

RAS, dexamethasone-induced 1

111.4

104.0

111.4

207.9

signal transduction

NM_004692

INA

internexin neuronal intermediate filament protein, alpha

6.5

9.8

4.6

4.6

cell adhesion and cytoskeleton

AI668588

SPTAN1

Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)

16.0

27.9

26.0

26.0

cell adhesion and cyctoskeleton

NM_005382

NEFM

neurofilament, medium polypeptide 150kDa

29.9

36.8

26.0

55.7

cell adhesion and cytoskeleton

U26662

NPTX2

neuronal pentraxin II

45.3

52.0

32.0

34.3

cell communication

NM_002105

H2AFX

H2A histone family, member X

10.6

13.9

7.5

13.0

DNA / chromosome

NM_003655

CBX4

chromobox homolog 4 (Pc class homolog, Drosophila)

24.3

29.9

14.9

36.8

DNA/chromosome

AL832081

ZNF131

Zinc finger protein 131

4.3

7.0

6.1

9.8

transcription

T79183

JAZF1

JAZF zinc finger 1

5.7

4.9

7.5

8.6

transcription

D42040

BRD2

bromodomain containing 2

6.1

9.2

6.1

8.6

transcription

NM_001452

FOXF2

forkhead box F2

6.5

14.9

11.3

16.0

transcription

NM_005904

SMAD7

SMAD family member 7

7.0

9.8

7.0

12.1

transcription

AF193855

ZIC2

Zic family member 2 (odd-paired homolog, Drosophila)

13.0

55.7

34.3

68.6

transcription

NM_001674

ATF3

activating transcription factor 3

13.9

16.0

36.8

26.0

transcription

AI459175

KLF3

Kruppel-like factor 3 (basic)

14.9

18.4

16.0

14.9

transcription

NM_004405

DLX2

distal-less homeobox 2

17.1

24.3

13.9

42.2

transcription

AW274658

ING1

Inhibitor of growth family, member 1

19.7

12.1

10.6

24.3

transcription

NM_002166

ID2

inhibitor of DNA binding 2, dominant negative helix-loop-helix protein

24.3

22.6

19.7

42.2

transcription

NM_002448

MSX1

msh homeobox 1

59.7

84.4

48.5

128.0

transcription

NM_152677

ZSCAN4

zinc finger and SCAN domain containing 4

97.0

362.0

55.7

147.0

transcription

AA761573

ZNF342

zinc finger protein 342

128.0

256.0

111.4

294.1

transcription

NM_002196

INSM1

insulinoma-associated 1

445.7

776.0

955.4

1782.9

transcription

AI906424

HNRPM

Heterogeneous nuclear ribonucleoprotein M

4.3

5.7

6.5

11.3

RNA / translation

AI445255

SFRS3

Splicing factor, arginine/serine-rich 3

13.0

14.9

14.9

21.1

RNA / translation

R17062

PABPC1

Poly(A) binding protein, cytoplasmic 1

32.0

39.4

48.5

90.5

RNA / translation

BF195994

PIAS2

Protein inhibitor of activated STAT, 2

4.3

5.7

4.6

9.2

protein folding and modification

U56725

HSPA2

heat shock 70kDa protein 2

5.7

8.6

4.0

5.7

protein folding and modification

AU158573

ABHD5

Abhydrolase domain containing 5

13.0

18.4

11.3

19.7

protein folding and modification

NM_000104

CYP1B1

cytochrome P450, family 1, subfamily B, polypeptide 1

6.1

6.5

13.0

18.4

development

NM_001529

HHEX

homeobox, hematopoietically expressed

17.1

48.5

97.0

68.6

development

NM_002405

MFNG

MFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase

4.0

8.0

4.6

8.6

developmental process

NM_000361

THBD

thrombomodulin

9.8

11.3

5.7

8.6

biological regulation

NM_000499

CYP1A1

cytochrome P450, family 1, subfamily A, polypeptide 1

4.3

4.9

5.3

7.5

cellular metabolism

AI625747

ADRB1

adrenergic, beta-1-, receptor

6.1

18.4

7.5

10.6

cellular metabolism

NM_003895

SYNJ1

synaptojanin 1

6.5

13.0

7.5

11.3

cellular metabolism

NM_000558

HBA1

hemoglobin, alpha 1

55.7

84.4

34.3

137.2

transport