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Table 4 Amino acid composition (hydrophilic, hydrophobic and neutral amino acids) in HVR1 of E2 protein

From: Characterization of Hepatitis C Virus genotype 3a Hypervariable region 1 in patients achieved rapid virological response to alpha interferon and Ribavirin Combination therapy

 

Hydropathic composition

HVR 1

Hydrophobic

Neutral

Hydrophillic

RR group (15 variants)

Leu (L) 7.87

Thr (T) 15.28

Arg (R) 3.94

 

Ile (I) 1.85

Glu (E)-

Lys (K)3.94

 

Phe (F) 3.47

Gly (G) 12.73

Asn (N) 5.09

 

Trp (W) .23

Ser (S) 18.29

His (H) 3.01

 

Val (V) 5.56

Gln (Q) 4.17

Pro (P) 1.62

 

Met (M) -

Asp (D) .23

 
 

Cys (C) -

  
 

Tyr (Y) 2.78

  
 

Ala (A) 9.95

  

Average

31.71

50.7

17.6

BT group (14 variants)

Leu (L) 6.42

Thr (T) 10.62

Arg (R) 5.19

 

Ile (I) .25

Glu (E) -

Lys (K)3.21

 

Phe (F) 4.44

Gly (G) 18.52

Asn (N) 2.72

 

Trp (W) -

Ser (S) 11.60

His (H) 3.70

 

Val (V) 5.43

Gln (Q) 6.67

Pro (P) 3.70

 

Met (M) -

Asp (D) 2.22

 
 

Cys (C) -

  
 

Tyr (Y) 3.95

  
 

Ala (A) 11.36

  

Average

31.85

49.63

18.52

  1. Comparison of average composition of twenty amino acids between rapid responders and breakthrough responders. Average composition of hydrophilic, hydrophobic and neutral amino acids in HVR1 rapid responders (R.R) and breakthrough responders (B.T)
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Virology Journal

ISSN: 1743-422X