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Table 4 Top 10 down-regulated pathways in C-33A cells expressing E2.

From: HPV16 E2 could act as down-regulator in cellular genes implicated in apoptosis, proliferation and cell differentiation

Cellular Pathway

No. genes altered

Wnt signaling pathway

28

PDGF signaling pathway

22

Angiogenesis

20

Inflammation mediated by chemokine and cytokine signaling pathway

20

Integrin signalling pathway

16

TGF-beta signaling pathway

13

p53 pathway

12

FGF signaling pathway

11

Apoptosis signaling pathway

10

PI3 kinase pathway

10

  1. Cellular Pathways with the greatest number of genes down-regulated by HPV16 E2 were selected as main pathways altered by E2. Ontological analysis was based on the algorithm used by PANTHER system (Protein ANalysis Through Evolutionary Relationships).
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Virology Journal

ISSN: 1743-422X