Skip to main content

Table 2 Highly down-regulated genes in C-33A cells by HPV16 E2 expression

From: HPV16 E2 could act as down-regulator in cellular genes implicated in apoptosis, proliferation and cell differentiation

Gene ID

Symbol

Name

Fold Change

NM_001872

CPB2

Carboxypeptidase B2

-8.5

NM_024610

HSPBAP1

HSPB (heat shock 27 kDa) associated protein 1

-8.2

NM_022118

RBM26

RNA binding motif protein 26

-8.2

NM_017819

RG9MTD1

RNA (guanine-9-) methyltransferase domain containing 1

-8.1

NM_005319

HIST1H1C

histone cluster 1, H1c

-7.9

NM_000859

HMGCR

3-hydroxy-3-methylglutaryl-Coenzyme A reductase

-7.9

NM_003829

MPDZ

Multiple PDZ domain protein

-7.8

NM_017806

LIME1

Lck interacting transmembrane adaptor 1

-7.5

NM_005166

APLP1

Amyloid beta (A4) precursor-like protein 1

-7.5

NM_015985

ANGPT4

Angiopoietin 4

-7.3

NM_016283

TAF9

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor

-7.0

NM_000808

GABRA3

Gamma-aminobutyric acid (GABA) A receptor, alpha 3

-7.0

NM_005264

GFRA1

GDNF family receptor alpha 1

-7.0

NM_003420

ZNF35

Zinc finger protein 35

-7.0

NM_016179

TRPC4

Transient receptor potential cation channel, subfamily C, member 4

-6.9

NM_020200

PRTFDC1

Phosphoribosyl transferase domain containing 1

-6.9

NM_014736

KIAA0101

KIAA0101

-6.9

NM_020651

PELI1

Pellino homolog 1 (Drosophila)

-6.8

NM_006061

CRISP3

Cysteine-rich secretory protein 3

-6.8

NM_014626

TAAR2

Trace amine associated receptor 2

-6.8

NM_007048

BTN3A1

Butyrophilin, subfamily 3, member A1

-6.7

NM_007213

PRAF2

PRA1 domain family, member 2

-6.7

NM_024838

THNSL1

Threonine synthase-like 1 (S. cerevisiae)

-6.7

NM_012198

GCA

Grancalcin, EF-hand calcium binding protein

-6.6

NM_018938

PCDHB4

Protocadherin beta 4

-6.6

NM_006530

YEATS4

YEATS domain containing 4

-6.4

NM_000500

CYP21A2

Cytochrome P450, family 21, subfamily A, polypeptide 2

-6.4

NM_014547

TMOD3

Tropomodulin 3 (ubiquitous)

-6.4

NM_000228

LAMB3

Laminin, beta 3

-6.3

NM_002029

FPR1

Formyl peptide receptor 1

-6.3

NM_016508

CDKL3

Cyclin-dependent kinase-like 3

-6.3

NM_017779

DEPDC1

DEP domain containing 1

-6.3

NM_024612

DHX40

DEAH (Asp-Glu-Ala-His) box polypeptide 40

-6.3

NM_020666

CLK4

CDC-like kinase 4

-6.3

NM_007029

STMN2

Stathmin-like 2

-6.2

NM_012095

AP3M1

Adaptor-related protein complex 3, mu 1 subunit

-6.2

NM_018319

TDP1

Tyrosyl-DNA phosphodiesterase 1

-6.2

NM_024665

TBL1XR1

Transducin (beta)-like 1 X-linked receptor 1

-6.2

NM_012123

MTO1

Mitochondrial translation optimization 1 homolog (S. cerevisiae)

-6.2

NM_001285

CLCA1

Chloride channel accessory 1

-6.2

NM_025074

FRAS1

Fraser syndrome 1

-6.2

NM_017424

CECR1

Cat eye syndrome chromosome region, candidate 1

-6.1

NM_024756

MMRN2

Multimerin 2

-6.1

NM_002492

NDUFB5

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5

-6.1

NM_004549

NDUFC2

NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2

-6.1

NM_018128

TSR1

TSR1, 20S rRNA accumulation, homolog (S. cerevisiae)

-6.0

NM_000438

PAX3

Paired box 3

-6.0

NM_018991

STAG3L1

Stromal antigen 3-like 1

-6.0

NM_024576

OGFRL1

Opioid growth factor receptor-like 1

-6.0

NM_004249

RAB28

RAB28, member RAS oncogene family

-6.0

  1. Fold Change refers to differences in Z score values compared to expression in non-infected cells, analysis was perform using genArise software. Changes in gene expression with a cut-off < -6.0 was used and the p- value was calculated by Student's t-test.