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Table 2 Predicted phosphorylation and O-glycosylation sites on Claudin-1 protein

From: Claudin-1 required for HCV virus entry has high potential for phosphorylation and O-glycosylation

Substrate Position Phosphorylation prediction Kinase prediction O-glycosylation prediction Surface accessibility
   Netphos Disphos NetphosK Kinasephos YinOYang OGPET NetSurfP
Ser 24 N N - - N HP B
Thr 25 N N CDC2 - N LP B
Ser 34 N N PKA - N LP B
Thr 42 N N - MDD N VHP B
Ser 53 N N - - N LP B
Ser 56 N N DNAPK PKG N VHP B
Ser 58 P N PKC ATM, IKK N HP E
Thr 59 N N - PKG N VHP E
Ser 69 N N PKA - N LP B
Ser 74 N N - CKI N LP E
Ser 75 N N - CKI N HP E
Thr 76 N N - CDK N LP B
Thr 80 N N - - N LP B
Thr 99 P N PKC - N LP B
Thr 137 N N - - N LP B
Thr 153 Y N MAPK, GSK3 CDC2, MAPK N VHP B
Thr 167 N N PKC, CDC2 - N VHP B
Ser 173 N N PKA - N LP B
Ser 185 N N CDC2 - N LP B
Thr 190 P N PKA PKA N HP E
Thr 191 Y Y PKG PKC, PKA Y LP E
Ser 192 Y P - PKA, IKK, PKB Y LP E
Thr 195 Y Y MAPK, CDC5 PKC, MAPK, CDK N VHP E
Ser 205 Y Y PKG CDC2 Y VHP E
Ser 206 Y Y PKC - Y VHP E
  1. Y = yes (threshold > 0.5), P = probable (threshold > 0.1~0.5), N = No (threshold < 0.1), B = Buried surface, E = Exposed surface, VHP = very high potential (threshold ≥ 1.0), HP = high potential (threshold >0.8 < 1.0), LP = low potential (threshold <0.8)