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Table 2 Predicted phosphorylation and O-glycosylation sites on IGFBP-6 protein

From: Serine 204 phosphorylation and O-β-GlcNAC interplay of IGFBP-6 as therapeutic indicator to regulate IGF-II functions in viral mediated hepatocellular carcinoma

Substrate Position Phosphorylation prediction Kinase prediction O-glycosylation prediction Surface accessibility
   Netphos Disphos NetphosK Kinasephos YinOYang OGPET Scansite NetSurfP
Thr 2 Y Y MAPK, CDK5 - N LP - E
Ser 21 Y N MAPK, CDC2, GSK3 CAM2, CDC2, MAPK, CDK N LP - B
Ser 52 Y Y CK2 CDC2, ATM, IKK N VHP <1 E
Thr 75 P Y MAPK, CDK5 CDK N VHP <1 E
Ser 120 Y Y PKC, PKA PKG, CKI N LP - E
Thr 126 Y Y PKC, CDC2 PKC N VHP - E
Thr 143 N N - MDD Y VHP - E
Ser 144 Y Y - PKC, CDC2 Y HP >1 E
Thr 145 P Y PKC CDK, MDD Y HP >1 E
Thr 146 Y Y CDK5 CDC2, CDK Y HP >1 E
Ser 148 Y Y DNAPK, ATM PKA, CKI, ATM Y HP >1 E
Ser 152 Y N - CDC2, IKK Y VHP - E
Thr 158 P N - CK2 N LP - E
Ser 169 Y N PKC CAM2, CKI, IKK N LP <1 E
Thr 176 N Y PKC PKC N LP - E
Thr 184 Y N PKC PKC N LP - E
Ser 203 P Y - CKI, CDC2, IKK N VHP - E
Ser 204 Y Y PKC, ATM, DNAPK ATM Y HP >1 B
Ser 221 P Y GSK3 PKG, IKK N LP <1 B
Ser 225 Y Y GSK3 CDC2, CDK, ATM N LP >1 B
Ser 231 P Y - CDC2, CDK Y VHP - E
Ser 232 N Y CDK5 IKK, PKB Y NHP <1 B
Ser 233 P Y CDC2 IKK Y HP <1 E
Thr 236 N Y CDC2 - Y VHP - E
Ser 238 N Y - - Y - - E
Ser 239 N Y CDC2 - Y HP - E
  1. Y = yes (threshold >0.5), P = probable (threshold > 0.1~0.5), N = No (threshold <0.1), VHP = very high potential (threshold ≥1.0), HP = high potential (threshold >0.8 <1.0), LP = low potential (threshold <0.8), <1 = low surface accessibility, >1 = high surface accessibility, 1 = low potential for solvent accessibility, 2 = high potential for solvent accessibility, B = Buried surface, E = Exposed surface,
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Virology Journal

ISSN: 1743-422X