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Table 2 Differential gene expression in brains of VEEV infected ICAM-1 WT mice (n = 3) as compared to IKO mice (n = 3) at 96 hr pi.

From: Role of adhesion molecules and inflammation in Venezuelan equine encephalitis virus infected mouse brain

Position RefSeq Number Symbol Description IKO Mean±SEM WT
Mean±SEM
Fold Change
(IKO/WT)
7 NM_011332 Ccl17 Chemokine (C-C motif) ligand 17 (Ccl17) 73.57 (A) P-IKO
13 NM_019577 Ccl24 Chemokine (C-C motif) ligand 24 (Ccl24) (A) 273.69 POR P-WT
22 NM_009912 Ccr1 Chemokine (C-C motif) receptor 1 (Ccr1) 132.24 ± (40.75) 28.80 POR 4.59
35 NM_019494 Cxcl11 Chemokine (C-X-C motif) ligand 11 (Cxcl11) 435.04 ± (167.36) 690.98 ± (322.64) 0.63
37 NM_018866 Cxcl13 Chemokine (C-X-C motif) ligand 13 (Cxcl13) 163.29 POR 245.09 ± (156.61) PTwR 0.67
49 NM_008337 Ifng Interferon gamma (Ifng) 211.35 ± (21.67) PTwR 122.81 ± (12.68) PTwR 1.72
51 NM_010548 Il10 Interleukin 10 (Il10) (A) 57.40 ± (43.51) PTwR P-WT
68 NM_008362 Il1r1 Interleukin 1 receptor, type I (Il1r1) 119.93 POR (A) P-IKO
69 NM_010555 Il1r2 Interleukin 1 receptor, type II (Il1r2) 287.27 POR 172.19 ± (94.76) PTwR 1.67
73 NM_016971 Il22 Interleukin 22 (Il22) (A) 186.84 POR P-WT
74 NM_008368 Il2rb Interleukin 2 receptor, beta chain (Il2rb) 151.12 POR 31.83 POR 4.75
93 NM_011101 Prkca Protein kinase C, alpha (Prkca) 60.8 POR (A) P-IKO
94 NM_009007 Rac1 RAS-related C3 botulinum substrate 1 (Rac1) 195.79 ± (6.81) PTwR 105.57 ± (81.61) PTwR 1.85
95 NM_007926 Scye1 Small inducible cytokine subfamily E, member 1 (Scye1) 385.53 ± (137.18) 243.61 ± (159.47) 1.58
96 NM_009263 Spp1 Secreted phosphoprotein 1 (Spp1) 693.01 ± (74.26) 389.60 ± (127.58) 1.78
104 NM_133211 Tlr7 Toll-like receptor 7 (Tlr7) 176.40 ± (87.47) PTwR 35.74 ± (22.32) PTwR 4.94
107 NM_013693 Tnf Tumor necrosis factor (Tnf) 74.90 ± (8.85) PTwR 193.78 POR 0.39
112 NM_008510 Xcl1 Chemokine (C motif) ligand 1 (Xcl1) 76.09 ± (42.81) PTwR (A) P-IKO
  1. Average expression values of gene are given. Where gene expression was detected in only one biological sample and not the replicates, the gene expression value is followed by POR (p resent in o ne r eplicate), similarly where the gene expression was detected in two biological replicates the gene expression value is followed by PTwR (p resent in tw o r eplicates). The fold expression values are derived by dividing average expression (or expression value from one or two replicates) of VEEV infected IKO samples with average expression (or expression value from one replicate) of VEEV infected ICAM WT samples and vice versa. PI = Expressed only in VEEV infected samples, PC = Expressed in uninfected saline control samples only, (A) = absent. Values are expressed as ± SEM.
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