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Table 2 Differential gene expression in brains of VEEV infected ICAM-1 WT mice (n = 3) as compared to IKO mice (n = 3) at 96 hr pi.

From: Role of adhesion molecules and inflammation in Venezuelan equine encephalitis virus infected mouse brain

Position

RefSeq Number

Symbol

Description

IKO Mean±SEM

WT

Mean±SEM

Fold Change

(IKO/WT)

7

NM_011332

Ccl17

Chemokine (C-C motif) ligand 17 (Ccl17)

73.57

(A)

P-IKO

13

NM_019577

Ccl24

Chemokine (C-C motif) ligand 24 (Ccl24)

(A)

273.69 POR

P-WT

22

NM_009912

Ccr1

Chemokine (C-C motif) receptor 1 (Ccr1)

132.24 ± (40.75)

28.80 POR

4.59

35

NM_019494

Cxcl11

Chemokine (C-X-C motif) ligand 11 (Cxcl11)

435.04 ± (167.36)

690.98 ± (322.64)

0.63

37

NM_018866

Cxcl13

Chemokine (C-X-C motif) ligand 13 (Cxcl13)

163.29 POR

245.09 ± (156.61) PTwR

0.67

49

NM_008337

Ifng

Interferon gamma (Ifng)

211.35 ± (21.67) PTwR

122.81 ± (12.68) PTwR

1.72

51

NM_010548

Il10

Interleukin 10 (Il10)

(A)

57.40 ± (43.51) PTwR

P-WT

68

NM_008362

Il1r1

Interleukin 1 receptor, type I (Il1r1)

119.93 POR

(A)

P-IKO

69

NM_010555

Il1r2

Interleukin 1 receptor, type II (Il1r2)

287.27 POR

172.19 ± (94.76) PTwR

1.67

73

NM_016971

Il22

Interleukin 22 (Il22)

(A)

186.84 POR

P-WT

74

NM_008368

Il2rb

Interleukin 2 receptor, beta chain (Il2rb)

151.12 POR

31.83 POR

4.75

93

NM_011101

Prkca

Protein kinase C, alpha (Prkca)

60.8 POR

(A)

P-IKO

94

NM_009007

Rac1

RAS-related C3 botulinum substrate 1 (Rac1)

195.79 ± (6.81) PTwR

105.57 ± (81.61) PTwR

1.85

95

NM_007926

Scye1

Small inducible cytokine subfamily E, member 1 (Scye1)

385.53 ± (137.18)

243.61 ± (159.47)

1.58

96

NM_009263

Spp1

Secreted phosphoprotein 1 (Spp1)

693.01 ± (74.26)

389.60 ± (127.58)

1.78

104

NM_133211

Tlr7

Toll-like receptor 7 (Tlr7)

176.40 ± (87.47) PTwR

35.74 ± (22.32) PTwR

4.94

107

NM_013693

Tnf

Tumor necrosis factor (Tnf)

74.90 ± (8.85) PTwR

193.78 POR

0.39

112

NM_008510

Xcl1

Chemokine (C motif) ligand 1 (Xcl1)

76.09 ± (42.81) PTwR

(A)

P-IKO

  1. Average expression values of gene are given. Where gene expression was detected in only one biological sample and not the replicates, the gene expression value is followed by POR (p resent in o ne r eplicate), similarly where the gene expression was detected in two biological replicates the gene expression value is followed by PTwR (p resent in tw o r eplicates). The fold expression values are derived by dividing average expression (or expression value from one or two replicates) of VEEV infected IKO samples with average expression (or expression value from one replicate) of VEEV infected ICAM WT samples and vice versa. PI = Expressed only in VEEV infected samples, PC = Expressed in uninfected saline control samples only, (A) = absent. Values are expressed as ± SEM.
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Virology Journal

ISSN: 1743-422X