Positive selection on hemagglutinin and neuraminidase genes of H1N1 influenza viruses

Table 2 Positively selected sites in neuraminidase from viruses from different clusters

Dataset	Description	Number of sequences	Length of alignment (bp)	Number of sites under positive selection		Positively selected sites¹
				SLAC	FEL	SLAC	FEL
2.1	Avian strains	137	1368	0	0
2.2	North American swine strains	171	1368	3	7	46^TG, 396^B,453^T	46^TG,53^T,75,127,285,339^B,453^T
2.3	Eurasian swine strains	92	1368	0	1		75
2.4	Seasonal human strains	1735	1371	5	6	84,151,222,275^A,382	84,151,275^A,344^B,365^BG,382
2.5	Pandemic 2009 human strains	1397	1368	0	2		35,453^T

¹In this column, B indicates that the site lies in the B-cell antigenic regions [21]. G means that it is a potential glycosylation site. T indicates that the site lies in the T-cell antigenic regions [19]. We start numbering from the amino acids MNPN. A means that the site is associated with drug-resistance [7].

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