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Figure 2 | Virology Journal

Figure 2

From: Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of coxsackievirus b3-induced viral myocarditis reduces myocardium inflammation

Figure 2

Evaluation of the severity of VMC. A, The value of heart weight/body weight (HW/BW) in different groups. The value for each group was 0.42 ± 0.07%, 0.41 ± 0.04%, 0.50 ± 0.05% and 0.52 ± 0.04%, respectively. B, The pathological scores in different groups. Scores for each group were 0.0 ± 0.0, 0.4 ± 0.5, 3.0 ± 0.0 and 2.8 ± 0.4 respectively. Each point represents an individual mouse. C, Representative of histopathological images in heart tissue (H&E, original magnification×400), a: Normal group; b: IL-17mAb group; c: Isotype control group; d: PBS group. D, Representative of IL-17 Immunohistochemistry images in heart tissue (dark brown granules, original magnification×400). a: Normal group; b: IL-17mAb group; c: Isotype control group; d: PBS group. E, Morphometric quantitation of IL-17 protein expression in myocardium. IOD in different groups were 36.04 ± 4.17, 106.41 ± 12.10, 2500.95 ± 65.83 and 2029.63 ± 69.21 respectively. Representative myocardial sections from normal (n = 8), IL-17mAb (n = 7), isotype control (n = 4) and PBS (n = 5) mice. △P > 0.05, *P < 0.05. Data are mean ± SD.

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Virology Journal

ISSN: 1743-422X