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Figure 3 | Virology Journal

Figure 3

From: Histone deacetylase 3, not histone deacetylase 2, interacts with the major immediate early locus of human cytomegalovirus

Figure 3

HDAC inhibitors enhance viral replication. HFF cells were infected with the AD169 strain of HCMV at MOI = 0.1 (panel A) and MOI = 5 (panel B) both in the presence and absence of TSA (250 nM). At different times postinfection, virus titer was determined using the plaque formation assay. Data are expressed as the average of three independent experiments. As seen in panel A and B, the production of infectious viral particles with TSA is approximately 10-fold higher at its maximum than without TSA.

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Virology Journal

ISSN: 1743-422X