Table 1 Significantly enriched Gene Ontology terms in response to infection with pandemic H1N1(2009) and seasonal H1N1 influenza viruses
A. Pandemic H1N1 | A. Seasonal H1N1 | ||||
|---|---|---|---|---|---|
Term | % | P-Value | Term | % | P-Value |
regulation of cell proliferation | 30.2 | 2.70E-13 | regulation of apoptosis | 27 | 1.80E-17 |
regulation of apoptosis | 28.1 | 2.00E-11 | regulation of cell proliferation | 20.9 | 1.60E-10 |
leukocyte activation | 15.6 | 1.20E-09 | positive regulation of apoptosis | 14.7 | 1.50E-09 |
response to cytokine stimulus | 10.4 | 3.50E-09 | regulation of cell cycle | 12.9 | 2.40E-09 |
regulation of protein kinase activity | 15.6 | 1.00E-07 | negative regulation of apoptosis | 12.9 | 7.60E-09 |
lymphocyte activation and immune response | 12.5 | 1.30E-07 | protein amino acid phosphorylation | 17.2 | 2.00E-08 |
cytokine-mediated signaling pathway | 8.3 | 5.20E-07 | lymphocyte activation | 8.6 | 7.20E-07 |
positive regulation of signal transduction | 12.5 | 6.10E-06 | immune system development | 9.8 | 1.00E-06 |
positive regulation of transcription from RNA polymerase II promoter | 13.5 | 9.60E-06 | transmembrane receptor protein tyrosine kinase signaling pathway | 8 | 1.50E-05 |
inflammatory response | 11.5 | 8.40E-05 | regulation of DNA replication | 4.3 | 9.20E-05 |
regulation of I-kappaB kinase/NF-kappaB cascade | 7.3 | 9.90E-05 | positive regulation of B cell activation | 2.5 | 6.90E-03 |
MAPKKK cascade | 8.3 | 2.90E-04 | JAK-STAT cascade | 2.5 | 1.10E-02 |