Figure 2
From: Influenza A virus NS1 gene mutations F103L and M106I increase replication and virulence
103L, 106I and 103L+106I mutations enhance viral tropism in BALB/c lungs. BALB/c mice were infected intransally with 105 pfu and lungs were collected 2 dpi. The lungs were inflated and fixed with 3.7% formaldehyde and lung sections were stained with anti-PR8 antibody. The bronchiolar regions are indicated by an arrow. A. Mock uninfected lungs B. rPR8-HK-NS-WT infected lungs C. rPR8-HK-NS-F103L infected lungs D. rPR8-HK-NS-M106I infected lungs E. rPR8-HK-NS-F103L + M106I infected lungs.