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Table 1 Swiss mouse neurovirulence of YF 17D viruses

From: Biological and immunological characterization of recombinant Yellow Fever 17D Viruses expressing a Trypanosoma cruzi Amastigote Surface Protein-2 CD8+T cell epitope at two distinct regions of the genome

Inoculation Dose
(log 10 PFU)
Mouse challenge
% mortality (dead/tested)
AST
± SD (days) b
Control a - 0 (0/30) -
YF 17DD (vaccine) 3.0 97 (29/30) 10 ± 1.8
YF17D/NS2B3/Tc 3.0 27 (8/30)* 12 ± 4.1
YF17D/E200/Tc 3.0 3 (1/30)* 13 ± 0.0
  1. a The mouse control group was inoculated with only Earle's 199 medium by the intracerebral route
  2. b AST, Average Survival Time ± Standard Deviation (SD)
  3. * P < 0.05, logrank test (Mantel-Cox) test