Figure 2
From: Antibody dependent enhancement infection of Enterovirus 71 in vitro and in vivo
Lower concentration of IVIG enhanced the mortality of EV71-infected mice. Groups of 1-day-old mice (n = 11) were injected with 1 LD50 of AH08/06 strain pre-mixed with varying concentration of IVIG. The mortality was further monitored for 2 weeks. (A) Kaplan-Meier survival curves were analyzed by the log-rank test and compared to curves of the PBS controls. Significant differences are indicated by asterisks. (B) Mortality curves of mice treated with different IVIG dilutions. 10-2 dilution of IVIG resulted in 80% death in EV71-infected mice.