Characterization of variants in the promoter of BZLF1 gene of EBV in nonmalignant EBV-associated diseases in Chinese children

Table 2 The frequency of EBV BZLF1 gene promoter zone (Zp) variants in each EBV-related disease group.^#

Zp-variant %(n/N)	IM (n = 88)	HLH (n = 46)	CAEBV (n = 32)	Controls (n = 40)
P	84.1 (74/88)	80.4 (37/46)	56.3 (18/32)^△	85.0 (34/40)
V3	5.7 (5/88)	43.5 (20/46)^△	81.3 (26/32)^△	2.5 (1/40)
V4	12.5 (11/88)	6.5 (3/46)	0	15.0 (6/40)
V1	11.4 (10/88)	0	0	10.0 (4/40)

^#The distribution of Zp subtypes involved all co-existence variants-IM included P(n = 61), V3(n = 3), V1(n = 4), V4(n = 6), P+V1(n = 6), P+V3(n = 2), P+V4(n = 5); EBV-HLH included P(n = 23), V3(n = 8), V4(n = 1), P+V3(n = 12), P+V4(n = 2); CAEBV included P(n = 6), V3(n = 14), P+V3(n = 12); controls included P(n = 29), V3 (n = 1), V1(n = 3), V4(n = 4), P+V1(n = 1), P+V4(n = 2)
^△(P ≤ 0.01) vs other groups

ISSN: 1743-422X