K18 Phosphorylation in normal, chronic non-cirrhotic hepatitis and cirrhosis livers. (A) Representative immunoblots of tubulin, K18, Ser33 and Ser52 phosphorylated K18 (K18 pSer33 and K18 pSer52, respectively) from livers of indicated sources. (B) Relative levels of Ser33 phosphorylated K18 from livers of healthy donors (squares), and patients with chronic non-cirrhotic hepatitis (circles) and cirrhosis (triangles). The intensity of K18 of each sample was used to normalize that of K18 pSer33, with the average of each group is shown in the box. The P-values of pair-wise comparisons are indicated on the top. (C) Relative levels of Ser52 phosphorylated K18 from livers of indicated sources, with symbols as the same in B. The P-values are indicated on the top.