Figure 4

In vitro display of antigens on bacteriophage T4 capsid. Schematic representation of the T4 capsid decorated with large antigens, PA (83 kDa) and LF (89 kDa), or hetero-oligomeric anthrax toxin complexes through either Hoc or Soc binding [39, 41]. See text for details. The insets show electron micrographs of T4 phage with the anthrax toxin complexes displayed through Soc (top) or Hoc (bottom). Note the copy number of the complexes is lower with the Hoc display than with the Soc display.