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Figure 4 | Virology Journal

Figure 4

From: Reversible conformational change in herpes simplex virus glycoprotein B with fusion-from-without activity is triggered by mildly acidic pH

Figure 4

Role of HSV-1 UL45 protein in the pH-triggered gB conformation change. (A) UL45 protein content of HSV-1 ANG path virions. Two-fold dilutions of HSV-1 KOS or ANG path were blotted to nitrocellulose membrane. Blots were probed with polyclonal antibody specific for gB or UL45. (B) Reversible, pH-dependent conformational change in gB from virions lacking the UL45 protein. HSV-1 KOS UL45 D or KOS wild type virions were treated with pH as indicated in the legend to Figure 3A. Conformational change in gB was probed with the indicated antibodies.

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Virology Journal

ISSN: 1743-422X