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Figure 4 | Virology Journal

Figure 4

From: Human TOP1 residues implicated in species specificity of HIV-1 infection are required for interaction with BTBD2, and RNAi of BTBD2 in old world monkey and human cells increases permissiveness to HIV-1 infection

Figure 4

hu -TOP1 residues E236/N237 in crystal structure. A. Structure of TOP1 in covalent complex with topotecan (MMDB: 49892) shows active site (arrow), the cap region (core subdomains I and II, [20]), and residues E236 and N237 (yellow) within the box. B. Enlargement of boxed region in panel-A shows that E236 and N237 are solvent exposed.

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Virology Journal

ISSN: 1743-422X