Local hyperthermia decreases the expression of CCL-20 in condyloma acuminatum

Table 1 The mRNA expressions of CCL-20, TNF-α, IL-1α in CA and normal skin subjected to different hyperthermia temperature.

	fresh		37°C		42°C		45°C
	CA	Normal skin	CA	Normal skin	CA	Normal skin	CA	Normal skin
CCL-20	1037.8 ± 139.8^##	0.96 ± 0.11	899.3 ± 198.9^##	0.86 ± 0.23	128.1 ± 45.4**^##	1.06 ± 0.38	140.2 ± 36.3**^##	2.41 ± 0.7*
TNF-α	2.43 ± 0.54^#	1.05 ± 0.19	1.47 ± 0.41	1.09 ± 0.08	1.73 ± 0.32	0.68 ± 0.17	1.24 ± 0.57	1.16 ± 0.24
IL-1α	122.48 ± 51.6^##	1.09 ± 0.17	78.8 ± 14.46^##	0.95 ± 0.15	23.5 ± 6.39*^##	0.74 ± 0.13	7.94 ± 1.44*	5.08 ± 2.63*

Compared with fresh and 37°C group, the expressions of CCL-20, IL-1α mRNA were significantly decreased after local hyperthermia at 42°C and 45°C in CA; In normal skin, CCL-20, IL-1α mRNA expressions increased significantly after hyperthermia at 45°C compared with those in fresh and 37°C group; The expressions of TNF-α mRNA remained unchanged in spite of the temperature variation in normal skin and CA. (*p < 0.05; ** p < 0.01 versus untreated and 37°C group); The expressions of CCL-20 mRNA in CA were all significantly higher than those in normal skin at different temperatures. The expressions of TNF-α mRNA in CA were higher than that in normal skin only in untreated group. The expressions of IL-1α mRNA in CA were significantly higher than those in normal skin except for 45°C group (^#p < 0.05; ^## p < 0.01 versus normal skin);

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