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Table 1 Current Clinical Trials for siRNA Therapeutics

From: Selective gene silencing by viral delivery of short hairpin RNA

Disease Mode of administration Status Company
Age-related macular degeneration (AMD) Topical Phase II Allergan
Respiratory syncytial virus (RSV) Local/direct Phase II Alnylam
Liver cancer (HCC and others) Systemic Phase I Alnylam
Hepatitis B Virus (HBV) Systemic Phase I Nucleonics
Solid tumors Systemic/local Phase I Calando Silence Therapeutics AG
Acute renal failure Systemic Phase I Quark Pharmaceuticals/Pfizer
Diabetic macular edema Topical Phase II Silence/Quark/Pfizer
Metastatic melanoma Local/direct Phase I Duke University
Pachyonychia congenita Topical Phase Ia/b Transderm
High cholesterol Systemic Phase I Tekmira Pharmaceuticals Corporation
Asthma Systemic Phase II ZaBeCor Pharmaceuticals
HIV Direct Phase I/II Benitec/City of Hope