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Table 4 Genetic analysis of the aminoGoose/Guangdong/1/96isolates.

From: Genetic characterization of 2008 reassortant influenza A virus (H5N1), Thailand

 

HA

NA

Virus

HA Cleavage site

Receptor binding site

N-link Glycosylation site

Antigenic site E

Antigenic site A

NA stalk region

Oseltamivir resistant amino acid

 

320-331

222

224

154-156

83

86

138

140

141

49-68

119

275

293

295

A/Goose/Guangdong/1/96

T PQRERRRKKR/G

Q

G

(NSA)

A

A

H

R

S

No deletion

E

H

R

N

A/Chicken/Thailand/CU-K2/04

SPQRERRRKKR/G

Q

G

NST

A

V

Q

K

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/CU-23/04

SPQRERRRKKR/G

Q

G

NST

A

V

Q

K

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/NIAH7540/04

SPQREK RRKKR/G

Q

G

NST

A

V

Q

K

S

20 aa deletion

E

H

R

N

A/duck/Thailand/NIAH8246/04

SPQREK RRKKR/G

Q

G

NST

A

V

Q

K

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/CK-160/05

SPQREK RRKKR/G

Q

G

NST

A

A

Q

K

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/PC-168/06

SPQRERRRKKR/G

Q

G

NST

A

V

L

K

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/PC-170/06

SPQREK RRKKR/G

Q

G

NST

P

A

Q

K

S

20 aa deletion

E

H

R

N

A/Duck/Thailand/CU-329/07

SPQREK RRKKR/G

Q

G

NST

A

A

L

N

P

20 aa deletion

E

H

R

N

A/Chicken/Thailand/ICRC-195/07

SPQRERRRKKR/G

Q

G

NST

A

V

L

R

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/ICRC-213/07

SPQRERRRKKR/G

Q

G

NST

A

V

Q

K

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/NS-339/08*

SPQRERRRKKR/G

Q

G

NST

A

V

L

R

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/PC-340/08*

SPQRERRRKKR/G

Q

G

NST

A

V

L

R

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/NS-341/08*

SPQRERRRKKR/G

Q

G

NST

A

V

L

R

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/NS-342/08*

SPQRERRRKKR/G

Q

G

NST

A

V

L

R

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/ST- 351/08*

SPQRERRRKKR/G

Q

G

NST

A

V

Q

K

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/CU-354/08*

SPQRERRRKKR/G

Q

G

NST

A

V

Q

K

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/NIAH115067/08

SPQRERRRKKR/G

Q

G

NST

A

V

L

R

S

20 aa deletion

E

H

R

N

A/Chicken/Thailand/NIAH114843/08

N PQRERRRKKR/G

Q

G

NST

A

V

L

R

S

20 aa deletion

E

H

R

N

Virus

Gene

 

M2

NS1

PB2

PB1

PA

NP

 

Amantadine-resistant amino acids

Human/Avian-like characteristics

5-aa deletion

Virulence determinant

Virulence determinant

Virulence

H/A

H/A

 

26

27

30

31

64

66

16

28

55

80-84

92

c-terminal

627

661

702

198

409

136

A/Goose/Guangdong/1/96

L

V

A

S

S

E

E

V

L

No

D

ESEV

E

A

K

K

S

M

A/Chicken/Thailand/CU-K2/04

I

V

A

N

A

A

E

V

L

Yes

D

ESEV

E

A

K

K

S

L

A/Chicken/Thailand/CU-23/04

I

V

A

N

A

A

E

V

L

Yes

N

ESEV

E

A

K

K

S

L

A/Chicken/Thailand/NIAH7540/04

I

V

A

N

A

A

E

V

L

Yes

D

ESEV

E

A

K

K

S

L

A/duck/Thailand/NIAH8246/04

I

V

A

N

A

A

E

V

L

Yes

D

ESEV

E

A

K

K

S

L

A/Chicken/Thailand/CK-160/05

I

V

A

N

A

A

E

V

L

Yes

D

ESEV

E

A

K

K

S

L

A/Chicken/Thailand/PC-168/06

I

V

A

N

A

A

E

V

L

Yes

D

ESEV

E

A

K

K

S

L

A/Chicken/Thailand/PC-170/06

I

V

A

N

A

A

E

V

L

Yes

D

ESEV

E

A

K

K

S

L

A/Duck/Thailand/CU-329/07

I

V

A

N

A

A

E

V

L

Yes

D

ESEV

E

A

K

K

S

L

A/Chicken/Thailand/ICRC-195/07

I

V

A

N

A

A

E

V

L

Yes

D

ESEV

E

A

K

K

S

L

A/Chicken/Thailand/ICRC-213/07

I

V

A

N

A

A

E

V

L

Yes

D

ESEF

E

A

K

K

S

L

A/Chicken/Thailand/NS-339/08*

I

V

A

N

A

A

E

V

F

Yes

D

ESEV

E

A

K

K

S

L

A/Chicken/Thailand/PC-340/08*

I

V

A

N

A

A

E

V

F

Yes

D

ESEV

E

A

K

K

S

L

A/Chicken/Thailand/NS-341/08*

I

V

A

N

A

A

E

V

F

Yes

D

ESEV

E

A

K

K

S

L

A/Chicken/Thailand/NS-342/08*

I

V

A

N

A

A

E

V

F

Yes

D

ESEV

E

A

K

K

S

L

A/Chicken/Thailand/ST- 351/08*

I

V

A

N

A

A

E

V

L

Yes

D

ESEV

E

A

K

K

S

L

A/Chicken/Thailand/CU-354/08*

I

V

A

N

A

A

E

V

L

Yes

D

ESEV

-

-

-

K

-

L

A/Chicken/Thailand/NIAH115067/08*

I

V

A

N

A

A

E

V

F

Yes

D

ESEV

E

A

K

K

S

L

A/Chicken/Thailand/NIAH114843/08*

I

V

A

N

A

A

E

V

L

Yes

D

ESEV

E

A

K

K

S

L

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Virology Journal

ISSN: 1743-422X