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Table 2 Significantly enriched Gene Ontology terms in response to RG modified H5N1 and highly pathogenic H5N1 infection.

From: Host gene expression profiling in influenza A virus-infected lung epithelial (A549) cells: a comparative analysis between highly pathogenic and modified H5N1 viruses

GO Term (Biological processes) Gene Count P-value
RG modified H5N1 (A/India/NIV/2006(H5N1)-PR8-IBCDC-RG7)
GO:0042981~regulation of apoptosis 45 4.45E-19
GO:0042127~regulation of cell proliferation 36 1.99E-12
GO:0043066~negative regulation of apoptosis 23 8.59E-11
GO:0043065~positive regulation of apoptosis 25 1.02E-10
GO:0051726~regulation of cell cycle 21 1.09E-09
GO:0006468~protein amino acid phosphorylation 28 7.60E-09
GO:0045859~regulation of protein kinase activity 19 7.55E-08
GO:0019221~cytokine-mediated signaling pathway 10 9.14E-08
GO:0016477~cell migration 16 5.87E-07
GO:0000086~G2/M transition of mitotic cell cycle 6 3.15E-06
GO:0051384~response to glucocorticoid stimulus 8 2.90E-05
GO:0043122~regulation of I-kappaB kinase/NF-kappaB cascade 9 2.96E-05
GO:0034330~cell junction organization 7 4.44E-05
GO:0006260~DNA replication 11 6.29E-05
GO:0046649~lymphocyte activation 11 9.26E-05
GO:0045321~leukocyte activation 12 1.01E-04
HPAI-H5N1 (A/Chicken/India/WB-NIV2664/2008)
GO:0042981~regulation of apoptosis 29 1.35E-13
GO:0042127~regulation of cell proliferation 26 2.83E-11
GO:0043066~negative regulation of apoptosis 17 1.27E-09
GO:0006954~inflammatory response 15 2.81E-08
GO:0045597~positive regulation of cell differentiation 13 3.55E-08
GO:0043065~positive regulation of apoptosis 16 1.38E-07
GO:0001932~regulation of protein amino acid phosphorylation 11 2.14E-07
GO:0006952~defense response 18 5.11E-07
GO:0045321~leukocyte activation 12 5.73E-07
GO:0006979~response to oxidative stress 10 1.38E-06
GO:0010740~positive regulation of protein kinase cascade 10 1.61E-06
GO:0051726~regulation of cell cycle 13 1.87E-06
GO:0030098~lymphocyte differentiation 8 5.38E-06
GO:0046649~lymphocyte activation 10 6.80E-06
GO:0019221~cytokine-mediated signaling pathway 7 6.83E-06
GO:0048534~hemopoietic or lymphoid organ development 11 8.57E-06
GO:0006955~immune response 17 1.10E-05
GO:0030595~leukocyte chemotaxis 5 1.02E-04
GO:0042113~B cell activation 6 1.48E-04