Table 2 Significantly enriched Gene Ontology terms in response to RG modified H5N1 and highly pathogenic H5N1 infection.
GO Term (Biological processes) | Gene Count | P-value |
|---|---|---|
RG modified H5N1 (A/India/NIV/2006(H5N1)-PR8-IBCDC-RG7) | ||
GO:0042981~regulation of apoptosis | 45 | 4.45E-19 |
GO:0042127~regulation of cell proliferation | 36 | 1.99E-12 |
GO:0043066~negative regulation of apoptosis | 23 | 8.59E-11 |
GO:0043065~positive regulation of apoptosis | 25 | 1.02E-10 |
GO:0051726~regulation of cell cycle | 21 | 1.09E-09 |
GO:0006468~protein amino acid phosphorylation | 28 | 7.60E-09 |
GO:0045859~regulation of protein kinase activity | 19 | 7.55E-08 |
GO:0019221~cytokine-mediated signaling pathway | 10 | 9.14E-08 |
GO:0016477~cell migration | 16 | 5.87E-07 |
GO:0000086~G2/M transition of mitotic cell cycle | 6 | 3.15E-06 |
GO:0051384~response to glucocorticoid stimulus | 8 | 2.90E-05 |
GO:0043122~regulation of I-kappaB kinase/NF-kappaB cascade | 9 | 2.96E-05 |
GO:0034330~cell junction organization | 7 | 4.44E-05 |
GO:0006260~DNA replication | 11 | 6.29E-05 |
GO:0046649~lymphocyte activation | 11 | 9.26E-05 |
GO:0045321~leukocyte activation | 12 | 1.01E-04 |
HPAI-H5N1 (A/Chicken/India/WB-NIV2664/2008) | ||
GO:0042981~regulation of apoptosis | 29 | 1.35E-13 |
GO:0042127~regulation of cell proliferation | 26 | 2.83E-11 |
GO:0043066~negative regulation of apoptosis | 17 | 1.27E-09 |
GO:0006954~inflammatory response | 15 | 2.81E-08 |
GO:0045597~positive regulation of cell differentiation | 13 | 3.55E-08 |
GO:0043065~positive regulation of apoptosis | 16 | 1.38E-07 |
GO:0001932~regulation of protein amino acid phosphorylation | 11 | 2.14E-07 |
GO:0006952~defense response | 18 | 5.11E-07 |
GO:0045321~leukocyte activation | 12 | 5.73E-07 |
GO:0006979~response to oxidative stress | 10 | 1.38E-06 |
GO:0010740~positive regulation of protein kinase cascade | 10 | 1.61E-06 |
GO:0051726~regulation of cell cycle | 13 | 1.87E-06 |
GO:0030098~lymphocyte differentiation | 8 | 5.38E-06 |
GO:0046649~lymphocyte activation | 10 | 6.80E-06 |
GO:0019221~cytokine-mediated signaling pathway | 7 | 6.83E-06 |
GO:0048534~hemopoietic or lymphoid organ development | 11 | 8.57E-06 |
GO:0006955~immune response | 17 | 1.10E-05 |
GO:0030595~leukocyte chemotaxis | 5 | 1.02E-04 |
GO:0042113~B cell activation | 6 | 1.48E-04 |