Table 1 Summary of differentially expressed genes in response to infection with HPAI-H5N1 and RG modified H5N1 in A549 cell lines.
Time-points | Genes qualifying the quality criteria in replicated experiments | Differentially expressed genes (+/-1.5folds, p < 0.05) | Up-regulated genes | Down-regulated genes |
|---|---|---|---|---|
HPAI-H5N1 (A/Chicken/India/WB-NIV2664/2008) | ||||
4 h | 253 | 40 | 15 | 25 |
8 h | 208 | 24 | 13 | 11 |
16 h | 254 | 101 | 53 | 48 |
24 h | 309 | 111 | 53 | 58 |
RG Modified H5N1 (A/India/NIV/2006(H5N1)-PR8-IBCDC-RG7) | ||||
4 h | 262 | 60 | 36 | 24 |
8 h | 212 | 128 | 67 | 61 |
16 h | 237 | 109 | 58 | 51 |
24 h | 305 | 42 | 22 | 20 |