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Table 4 Amino acid residues in the G protein that may play a role in the determination of virulence [22].

From: Characterization of a VHS virus genotype III isolated from rainbow trout (Oncorhychus mykiss) at a marine site on the west coast of Norway

 

G protein residues

 

118

135

139

140

161

431

433

FR-07-71

Q

T

S

K

K

L

I

FR-07-71 mutants

  

I/N

R

R

 

T

Tr25

R

I

R

K

K

P

I

Tr25 mutants

  

N

N/E

   

FA281109

Q

A

S

K

K

L

I

Other GIII isolates

Q

A/T

S

K

K

L

I

  1. The FR-07-71 VHS virus isolate is highly virulent, while the mutant (07-71 mutant), Tr25 (an attenuated laboratory variant of FR-07-71), and Tr25 mutants have a low virulence. The VHS virus isolate (FA28.11.09) from rainbow trout in Norway share six out of seven amino acids with the virulent FR-07-71 strain.
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Virology Journal

ISSN: 1743-422X