Table 3 Analysis of unique amino acids for avian, human, classical swine and Eurasian swine lineages.

Equine

-

1

G

K

V

I

R

I

L

K

L

R

E

N

R

D

I

N 1

Avian

Avian

25

G

R

V

I

R

I

L

R

L

R

E

N24/S11

R

D

V

S 24/G1

Human (H5N1)

Avian

6

G

R

V

I

R

I

L

R

L

R

E

N

R

D

V

S 6

Human (Seasonal)

Human

11

D

K8/R3

I

L

V

V

I

K

P

K

D

S9/G2

K

E10/D

M8/V3

S 5/G6

Human (Pandemic)

Classical swine

8

G

R

I

I

I

I

I

R

L

R

E

N

R

D

M

S

Swine (Eurasian)

Eurasian swine

18

G

R

V

I15/M3

R

I16/V2

L

R15/K3

L

R

E

V15/I3

R

D

M17/I 1

S12/N5/G1

Swine (Classical)

Classical swine

8

G

R

V6/I2

I

V6/R2

I

I6/L2

K7/R

L

R

E

N

R

D

M

N7/R

Host

Lineage

n

Swine lineage

217

289

313

316

350

357

371

373

384

400

425

433

444

456

Equine

-

1

I

Y

F

I

T

Q

M

T

R

K

I

N

I

V

Avian

Avian

25

I24/M

Y

F

I

T

Q

M

A24/T1

R

R

I

T

I

V24/A1

Human (H5N1)

Avian

6

I

Y

F

I

T

Q5/K

M

A

R

R

I

T

I

V

Human (Seasonal)

Human

11

I3/S8

Y

Y

I

T

K

M

N8/A3

R

R

I

T

I

V

Human (Pandemic)

Classical swine

8

V

H

V

M

K

K

V

T

G8/R3

K

V

N

V

L

Swine (Eurasian)

Eurasian swine

18

I

Y

F16/L2

I

T

Q17/K1

M

T

K

R17/K1

I

T17/N1

I

V

Swine (Classical)

Classical swine

8

I7/V

H6/Y2

F

I

K

K

V

A

R

K

I7/V

N

V

L