Table 3 Summary of the results described in Figure 3.
| Â | Â | MOI | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
Cells and peptides | Virus | 0 | 0.001 | 0.005 | 0.01 | 0.05 | 0.1 | 0.5 | 1 | 5 | 10 |
HeLa P4 | WT | 0 | 0.05 ± 0.01 | 0.06 ± 0.01 | 0.09 ± 0.01 | 0.10 ± 0.01 | 0.12 ± 0.01 | 0.51 ± 0.02 | 1.02 ± 0.08 | 1.53 ± 0.09 | 1.68 ± 0.11 |
|  | ΔRev | 0 | 0.67 ± 0.04 | 1.34 ± 0.10 | 3.22 ± 0.15 | 3.42 ± 0.16 | 3.95 ± 0.18 | 5.13 ± 0.23 | 8.79 ± 0.37 | 17.59 ± 0.89 | 52.76 ± 2.21 |
LEDGF/p75-knockdown | WT | 0 | 0 | 0.01 ± 0.00 | 0 | 0 | 0 | 0.01 ± 0.00 | 0.04 ± 0.01 | 0.08 ± 0.01 | 0.23 ± 0.03 |
|  | ΔRev | 0 | 0.30 ± 0.03 | 0.60 ± 0.04 | 1.43 ± 0.08 | 1.52 ± 0.07 | 1.76 ± 0.09 | 2.28 ± 0.10 | 3.91 ± 0.13 | 7.83 ± 0.47 | 23.48 ± 1.34 |
HeLa P4 + INS 100 μM | WT | 0 | 0.39 ± 0.02 | 0.78 ± 0.02 | 1.57 ± 0.09 | 2.35 ± 0.14 | 3.30 ± 0.20 | 4.29 ± 0.35 | 5.14 ± 0.44 | 10.29 ± 0.99 | 30.86 ± 2.14 |
|  | ΔRev | 0 | 0.76 ± 0.03 | 1.52 ± 0.08 | 3.04 ± 0.14 | 4.56 ± 0.38 | 6.39 ± 0.71 | 8.30 ± 0.76 | 11.63 ± 1.01 | 19.93 ± 1.64 | 52.37 ± 3.42 |
LEDGF/p75-knockdown + INS 100 μM | WT | 0 | 0.09 ± 0.01 | 0.19 ± 0.02 | 0.37 ± 0.02 | 0.56 ± 0.03 | 0.78 ± 0.06 | 1.02 ± 0.09 | 1.22 ± 0.10 | 2.44 ± 0.18 | 7.33 ± 0.42 |
|  | ΔRev | 0 | 0.63 ± 0.04 | 1.26 ± 0.11 | 2.52 ± 0.18 | 3.79 ± 0.26 | 5.30 ± 0.44 | 6.89 ± 0.61 | 8.27 ± 0.74 | 16.54 ± 1.33 | 49.61 ± 3.11 |