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Table 1 Binding to LEDGF/p75.

From: Peptides derived from the HIV-1 integrase promote HIV-1 infection and multi-integration of viral cDNA in LEDGF/p75-knockdown cells

   

LEDGF

Peptide

Sequence

IN residues

Kd [μM]*

INS

WTAVQMAVFIHNFKRK

W+174-188

2.2 ± 0.7

INS K188A

WTAVQMAVFIHNFKRA

W+174-187+A

3.0 ± 1.5

INS K188E

WTAVQMAVFIHNFKRE

W+174-187+E

4.5 ± 2.0

  1. * Apparent K d according to ELISA system using LEDGF and BSA alone as control.
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Virology Journal

ISSN: 1743-422X