Table 1 Genome-wide SNP/indel attributes of CDV-R MPV.
From: Comparative whole genome sequence analysis of wild-type and cidofovir-resistant monkeypoxvirus
Locationa | Mutation | Amino Acid | Z79-ORFb | COP-ORFc | Gene | GenBank# |
|---|---|---|---|---|---|---|
6166 | T insertion | NA | IGd | NA | NA | NA |
6863 | G to A | P9S | 9 | unknown | ankyrin-like | AAY97204 |
11360 | T insertion | NA | 15 | unknown | ankyrin/host Range | AAY97210 |
13685 | C to T | A589T | 17 | C9L | ankyrin | AAY97212 |
19143 | C to T | NA | IGd | NA | NA | NA |
27141 | C deletion | A168Q | 32 | K2L | serine protease inhibitor-like protein SPI-3 | AAY97227 |
32192 | T deletion | H385L | 38 | F3L | Kelch-like | AAY97233 |
33518 | C to T | silent | 39 | I4L/F4L | ribonucleoside-diphosphate reductase | AAY97234 |
35560 | T deletion | NA | IGd | NA | NA | NA |
35593 | G to A | T68M | 42 | F7L | unknown | AAY97237 |
40212 | C to A | silent | 47 | F12L | IEV associated | AAY97242 |
44808 | C to T | R342H | 53 | E1L | poly-A polymerase catalytic subunit VP55 | AAY97248 |
48134 | A to T | NA | IGd | NA | NA | NA |
50728 | T to A | silent | 59 | E6R | unknown | AAY97254 |
53128 | T to C | silent | 61 | E8R | assoc.s with IV/IMV and cores; F10L kinase substrate | AAY97256 |
53738 | G to A | V256I | 61 | E8R | assoc.s with IV/IMV and cores; F10L kinase substrate | AAY97256 |
54066 | T to C | silent | 62 | E9L | DNA polymerase | AAY97257 |
54400 | G to A | T808M | 62 | E9L | DNA polymerase | AAY97257 |
54773 | C to T | A684T | 62 | E9L | DNA polymerase | AAY97257 |
54986 | C to T | A613T | 62 | E9L | DNA polymerase | AAY97257 |
55882 | G to A | A314V | 62 | E9L | DNA polymerase | AAY97257 |
58655 | T to C | silent | 65 | 01L | unknown | AAY97260 |
64425 | A insertion | NA | IGd | NA | NA | NA |
73563 | A deletion | NA | IGd | NA | NA | NA |
77811 | G to A | M207I | 85 | L1R | myristylprotein | AAY97280 |
82937 | C to T | silent | 93 | J4R | DNA-dependent RNA polymerase subunit rpo22 | AAY97288 |
84110 | G to A | silent | 95 | J6R | DNA-dependent RNA polymerase subunit rpo147 | AAY97290 |
84578 | A to C | K355N | 95 | J6R | DNA-dependent RNA polymerase subunit rpo147 | AAY97290 |
85471 | T to G | L653R | 95 | J6R | DNA-dependent RNA polymerase subunit rpo147 | AAY97290 |
89604 | G to A | silent | 99 | H4L | RNA polymerase-assoc. transcription factor RAP94 | AAY97294 |
89691 | C to T | M715I | 99 | H4L | RNA polymerase-assoc. transcription factor RAP94 | AAY97294 |
99891 | T to C | silent | 107 | D5R | NTPase, DNA replication | AAY97302 |
103281 | C to T | A289T | 110 | D8L | carbonic anhydrase/Virion | AAY97305 |
104948 | C to A | L42I | 111 | D9R | nudix-hydrolase/RNA decapping | AAY97307 |
107809 | C to T | H122Y | 114 | D12L | small capping enzyme, methyltransferase | AAY97309 |
108002 | G to A | S186N | 114 | D12L | small capping enzyme, methyltransferase | AAY97309 |
119244 | G to A | silent | 125 | A9L | membrane protein | AAY97320 |
129030 | C to T | S216L | 138 | A20R | DNA processivity factor | AAY97333 |
129340 | G to A | silent | 138 | A20R | DNA processivity factor | AAY97333 |
137047 | A to G | L324S | 145 | A25L | A type inclusion protein (CPXV) | AAY97340 |
138486 | ATCATC deletion | DD-dele | 146 | A26L | P4c: CWPVA27L, A-type inclusion protein | AAY97341 |
149213 | G to A | silent | 161 | A42R | profilin homolog | AAY97356 |
150527 | C to T | A284T | 164 | A44L | bifunctional hydroxysteroid dehydrogenase | AAY97356 |
151960 | T to C | silent | 166 | A46R | IL-1 signaling inhibitor | AAY97361 |
154086 | G deletion | frameshift | 169 | A48R | thymidylate kinase | AAY97364 |
162118 | C to T | H268Y | 178 | B2R/B3R | Schlafen ATPase | AAY97370 |
163857 | C to T | A271V | 179 | B4R | ankyrin | AAY97371 |
166078 | A to T | Q9H | 181 | B6R | ankyrin | AAY97373 |
168859 | T to A | NA | IGd | NA | NA | NA |
175168 | C to T | silent | 192 | B18R | IFN-α/β-receptor orthologue | AAY97385 |
176348 | T to C | silent | 193 | unknown | ankyrin | AAY97386 |
177838 | T insertion | NA | IGd | NA | NA | NA |
183499 | T to C | silent | 197 | CWP_B22R | surface glycoprotein | AAY97391 |
189631 | T to C | NA | IGd | NA | NA | NA |
190055 | A deletion | NA | IGd | NA | NA | NA |