Figure 10
From: Comparative whole genome sequence analysis of wild-type and cidofovir-resistant monkeypoxvirus
MPV CDV-R mutations mapped onto the 3D structures of the poxvirus D1/D12 mRNA capping enzyme. S186 which lies within the conserved motif 183-KCVSDSWLKDS (F, red residues) plays a major role in proper tertiary folding [54]. Yellow residues (E and F) designate the D12 hetero-dimerization motif [54]. D1 residues T84 (magenta) and S589 (teal) specify residues in closest proximity to the D12 S186N substitution (E). Illustrations were prepared using PyMol.