Clinical significance of 4 patients with chronic hepatitis B achieving HBsAg clearance by treated with pegylated interferon alpha-2a for less than 1 year: a short report

Table 1 Therapeutic efficacy of pegasys in 4 patients with chronic hepatitis B

Characteristics	Case 1	Case 2	Case 3	Case 4
Sex	Female	Male	Male	Male
Age(yr)	14	24	39	49
Course of disease^a(yr)	3	2	1	1
Therapy	Monotherapy	Monotherapy	Sequential therapy	Sequential therapy
Course of treatment^b(wk)	36	40	24	44
HBV DNA undetectable^c	Week 14	Week 16	Week 20	Week 14
ALT normalization	Week 36	Week 26	Week 23	Week 14
HBeAg seroconversion	Week 16	Week 22	Week 23	Week 38
HBsAg clearance	Week 17	Week 40	Week 24	Week 44
HBsAg seroconversion	Week 20	--	--	--

yr, year; wk, week; ALT, alanine aminotransferase; HBeAg, hepatitis B e antigen; HBsAg, hepatitis B surface antigen; HBV, hepatitis B virus.
^a interval between the first time when HBsAg-positive was detected and the date before treatment.
^b cumulate course between the first day of anti-HBV treatment and the date when complete response occurred.
^c HBV DNA<1000 copies/ml.

ISSN: 1743-422X