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Table 4 Selective pressure on different sites between human and avian influenza

From: Evolution of the M gene of the influenza A virus in different host species: large-scale sequence analysis

    Human Avian
Gene Domaina Position dN/dSb P-value dN/dS P-value
M1   115 0.07 0.0031 0.06 < 0.001
   121 0.11 0.039 0.07 < 0.001
   137 0.69 0.61 0.03 < 0.001
M2 ex 11 infc 0.017 inf < 0.001
  ex 16 6.18 0.021 5.06 0.044
  ex 20 Inf 0.094 inf < 0.001
  cy 54 1.36 0.50 0.50 0.12
  cy 57 3.62 0.050 inf 0.12
  cy 78 0.74 0.68 0.26 0.086
  cy 86 3.47 0.16 0.64 0.64
  cy 93 1.27 0.71 inf 0.067
  1. aEx indicates extracellular domain; Tr, transmembrane domain; and Cy, cytoplasmic domain.
  2. bdN/dS was calculated by eFEL.
  3. c"inf" means infinity as denominator is 0.
  4. Significance of the FEL test for positive selection levels is given as P-values, and underlined values indicate P-values for negative selection.
  5. Bold values are those deemed to indicate significantly positive or negative selection (P < 0.05).