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Table 4 Selective pressure on different sites between human and avian influenza

From: Evolution of the M gene of the influenza A virus in different host species: large-scale sequence analysis

   

Human

Avian

Gene

Domaina

Position

dN/dSb

P-value

dN/dS

P-value

M1

 

115

0.07

0.0031

0.06

< 0.001

  

121

0.11

0.039

0.07

< 0.001

  

137

0.69

0.61

0.03

< 0.001

M2

ex

11

infc

0.017

inf

< 0.001

 

ex

16

6.18

0.021

5.06

0.044

 

ex

20

Inf

0.094

inf

< 0.001

 

cy

54

1.36

0.50

0.50

0.12

 

cy

57

3.62

0.050

inf

0.12

 

cy

78

0.74

0.68

0.26

0.086

 

cy

86

3.47

0.16

0.64

0.64

 

cy

93

1.27

0.71

inf

0.067

  1. aEx indicates extracellular domain; Tr, transmembrane domain; and Cy, cytoplasmic domain.
  2. bdN/dS was calculated by eFEL.
  3. c"inf" means infinity as denominator is 0.
  4. Significance of the FEL test for positive selection levels is given as P-values, and underlined values indicate P-values for negative selection.
  5. Bold values are those deemed to indicate significantly positive or negative selection (P < 0.05).
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Virology Journal

ISSN: 1743-422X