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Table 3 Sites under positive selection for human influenza

From: Evolution of the M gene of the influenza A virus in different host species: large-scale sequence analysis

Gene Domaina Position dN/dSb eSLAC iSLAC tSLAC eFEL iFEL
M1   219 infc 0.0048 0.22 0.022 0.0032 0.013
M2 Ex 11 inf 0.074 0.23 0.33 0.017 0.0055
  Ex 12 inf 0.0068 0.32 0.022 0.0026 0.024
  Ex 13 inf 0.020 0.55 0.036 0.0025 0.064
  Ex 14 inf 0.069 0.37 0.19 0.019 0.025
  Ex 16 6.18 0.015 0.027 0.27 0.021 0.0017
  Ex 21 inf 0.071 0.37 0.19 0.036 0.040
  Ex 23 inf 0.052 0.27 0.19 0.037 0.024
  Tm 27 4.42 0.054 0.59 0.039 0.082 0.20
  Cy 57 3.62 0.21 0.16 0.57 0.050 0.024
  Cy 89 inf 0.002 0.12 0.016 0.0023 0.0046
  1. The significance of SLAC and FEL results for positive selection levels are given as P-values.
  2. aEx indicates extracellular domain; Tr, transmembrane domain; and Cy, cytoplasmic domain.
  3. bdN/dS was calculated by eFEL.
  4. c"inf" means infinity as denominator is 0.
  5. Bold values are those deemed to show significantly positive selection (P < 0.05).